Genetic deletion of HRP2 and HRP3 in Indian Plasmodium falciparum population and false negative malaria rapid diagnostic test

被引：110
作者：
Kumar, Navin [1 ]
Pande, Veena [2 ]
Bhatt, R. M. [3 ]
Shah, Naman K. [1 ]
Mishra, Neelima [1 ]
Srivastava, Bina [1 ]
Valecha, Neena [1 ]
Anvikar, Anupkumar R. [1 ]
机构：
[1] Natl Inst Malaria Res ICMR, New Delhi, India
[2] Kumaun Univ, Dept Biotechnol, Naini Tal, Uttarakhand, India
[3] RLTRI, Natl Inst Malaria Res Field Unit ICMR, Raipur, Madhya Pradesh, India
来源：
ACTA TROPICA | 2013年 / 125卷 / 01期
关键词：
Malaria; Pfhrp2; Pfhrp3; Genetic deletion; Rapid diagnostic tests; India; HISTIDINE-RICH PROTEINS; SEQUENCE VARIATION; PFHRP2; SENSITIVITY; PERFORMANCE; MICROSCOPY; REGION;
D O I：
10.1016/j.actatropica.2012.09.015
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Genetic polymorphisms in diagnostic antigens are important factors responsible lot variable performance of rapid diagnostic tests. Additionally, the failure of antigen expression due to gene deletion may also contribute to variable performance. We report Indian Plasmodium falciparum field isolates lacking both Pfhrp2 and Pfhrp3 genes leading to false negative results of rapid diagnostic tests. The study highlights need to determine the prevalence of P. falciparum isolates lacking these genes in larger field populations in India. (C) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：119 / 121
页数：3
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