Post-transplant lymphoproliferative disorders after heart or kidney transplantation at a single centre: Presentation and response to treatment

被引：5

作者：

Aversa, S. M. L. ^{[1
]}

Stragliotto, S. ^{[1
]}

Marino, D. ^{[1
]}

Calabrese, F. ^{[3
]}

Rigotti, P. ^{[4
]}

Marchini, F. ^{[4
]}

Gambino, A. ^{[5
]}

Feltrin, G. ^{[5
]}

Boso, C. ^{[2
]}

Canova, F. ^{[1
]}

Solda, C. ^{[1
]}

Mazzarotto, R. ^{[2
]}

Burra, P. ^{[6
]}

机构：

[1] IRCCS, Div Med Oncol, Ist Oncol Veneto, IT-35128 Padua, Italy

[2] IRCCS, Dept Radiotherapy, Ist Oncol Veneto, IT-35128 Padua, Italy

[3] Univ Padua, Dept Med Sci & Special Therapies, Padua, Italy

[4] Univ Padua, Kidney & Pancreas Transplantat Unit, Dept Med & Surg Sci, Padua, Italy

[5] Univ Padua, Dept Cardiothorac Sci, Padua, Italy

[6] Univ Padua, Dept Surg & Gastroenterol Sci, Padua, Italy

来源：

ACTA HAEMATOLOGICA | 2008年 / 120卷 / 01期

关键词：

post-transplant lymphoproliferative disorders; solid organ transplantation; weekly chemotherapy;

D O I：

10.1159/000155234

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Post-transplant lymphoproliferative disorders (PTLD) is a serious complication after solid organ transplantation. Reduction of immunosuppression (RI) alone is not able to control the disease. We report a prospective analysis of 30 patients with PTLD after heart or kidney transplantation. Only 5 of 30 patients, treated solely with RI, obtained a complete response. Five patients were treated heterogeneously; in the remaining 20, the efficacy and safety of a weekly anthracycline-based chemotherapy were assessed. Sixteen patients obtained a complete remission. One death was related to treatment. With a median follow-up of 36 months, 3-year overall survival was 63.3% and 57% for the entire group and the chemotherapy-treated group, respectively. Moreover, 4 second neoplasms were observed in the chemotherapeutic group. In this study, we demonstrated that most PTLD need other treatment than RI and a weekly regimen is manageable and has a favourable impact on long-term survival. Copyright (C) 2008 S. Karger AG, Basel.

引用

页码：36 / 46

页数：11

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