Effects of Antihypertensive Drugs on Arterial Stiffness

被引：104
作者：
Dudenbostel, Tanja [1 ]
Glasser, Stephen P. [1 ]
机构：
[1] Univ Alabama Birmingham, Vasc Biol & Hypertens Program, Div Cardiovasc Dis, Birmingham, AL 35294 USA
来源：
CARDIOLOGY IN REVIEW | 2012年 / 20卷 / 05期
关键词：
pulse wave analysis; pulse contour analysis; pulse wave velocity; pulse wave amplification; augmentation index; hypertension; PULSE-WAVE VELOCITY; CONVERTING ENZYME-INHIBITOR; CENTRAL AORTIC PRESSURE; CENTRAL BLOOD-PRESSURE; CARDIOVASCULAR EVENTS; INDEPENDENT PREDICTOR; RENIN INHIBITION; ALL-CAUSE; HYPERTENSION; MORTALITY;
D O I：
10.1097/CRD.0b013e31825d0a44
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review, we discuss the possible pathophysiological mechanisms and the role of arterial stiffness as a biomarker, a blood pressure independent predictor of cardiovascular morbidity and mortality. The effects of different antihypertensive drug classes on noninvasively assessed markers of arterial stiffness are also discussed. Current evidence will be reviewed regarding the effect of drugs on arterial stiffness, including the peripheral and central effects of angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, dihydropyridine calcium channel blockers, beta blockers (including vasodilating beta blockers), diuretics, and mineralocorticoid antagonists.
引用
收藏
页码：259 / 263
页数：5
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