Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

被引：16

作者：

Yoshikawa, M

Andoh, H

Ito, K

Suzuki, T

Kawaguchi, M

Kobayashi, H

Oka, T

Hashimoto, A ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Pharmacol, Isehara, Kanagawa 2591143, Japan

[2] Tokai Univ, Sch Med, Dept Psychiat & Behav Sci, Isehara, Kanagawa 2591143, Japan

[3] Tokai Univ, Sch Med, Dept Anesthesiol, Isehara, Kanagawa 2591143, Japan

[4] Tokyo Dent Coll, Dept Pharmacol, Mihama Ku, Chiba 2618502, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 525卷 / 1-3期

关键词：

D-amino acid oxidase; morphine; NMDA ( N-methyl-D-aspartate) receptor; D-serine; serine racemase;

D O I：

10.1016/j.ejphar.2005.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：94 / 97

页数：4

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