HLA DR15 Antigen Status Does Not Impact Graft-versus-Host Disease or Survival in HLA-Matched Sibling Transplantation for Hematologic Malignancies

被引：13

作者：

Battiwalla, Minoo ^{[1
]}

Ellis, Kristin ^{[2
]}

Li, Peigang ^{[2
]}

Pavletic, Steven Z. ^{[3
]}

Akpek, Gorgun ^{[4
]}

Hematti, Peiman ^{[5
]}

Klumpp, Thomas R. ^{[6
]}

Maziarz, Richard T. ^{[7
]}

Savani, Bipin N. ^{[8
]}

Aljurf, Mahmoud D. ^{[9
]}

Cairo, Mitchell S. ^{[10
]}

Drobyski, William R.

George, Biju ^{[11
]}

Hahn, Theresa ^{[12
]}

Khera, Nandita ^{[13
]}

Litzow, Mark R. ^{[14
]}

Loren, Alison W. ^{[15
]}

Saber, Wael ^{[2
]}

Arora, Mukta ^{[16
]}

Urbano-Ispizua, Alvaro ^{[17
]}

Cutler, Corey ^{[18
]}

Flowers, Mary E. D. ^{[13
]}

Spellman, Stephen R. ^{[19
]}

机构：

[1] NHLBI, NIH, Hematol Branch, Bethesda, MD 20892 USA

[2] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[3] NCI, NIH, Bethesda, MD 20892 USA

[4] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[5] Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA

[6] Temple Bone Marrow Transplant Program, Philadelphia, PA USA

[7] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[8] Vanderbilt Univ, Med Ctr, Brentwood, TN USA

[9] King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia

[10] New York Med Coll, Valhalla, NY 10595 USA

[11] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[12] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[13] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[14] Mayo Clin, Rochester, MN USA

[15] Univ Penn, Med Ctr, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[16] Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA

[17] Hosp Clin Barcelona, Dept Hematol, Barcelona, Spain

[18] Dana Farber Canc Inst, Div Hematol Malignancies, Boston, MA 02115 USA

[19] Ctr Int Blood & Marrow Transplant Res, Minneapolis, MN USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2012年 / 18卷 / 08期

关键词：

DR15; Hematopoietic stem cell transplantation (HSCT); GVHD; Survival; graft-versus-lymphoma; APLASTIC-ANEMIA PATIENTS; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; STEM-CELL TRANSPLANTATION; REDUCED RELAPSE RATE; IMMUNOSUPPRESSIVE THERAPY; MYELODYSPLASTIC SYNDROME; INCREASED FREQUENCY; POPULATION; HLA-DR15; DR2;

D O I：

10.1016/j.bbmt.2012.02.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The HLA class II DRB1 antigen DR15 is an important prognostic marker in immune-mediated marrow failure states. DR15 has also been associated with favorable outcomes (reduced acute graft-versus-host disease [aGVHD] and relapse) after allogeneic hematopoietic cell transplant. To elucidate the impact of DR15 on transplantation outcomes, we conducted a retrospective study of 2891 recipients of first allogeneic stem cell transplant from MLA-matched sibling donors for the treatment of acute leukemia, chronic myeloid leukemia, or myelodysplastic syndrome (MDS) between 1990 and 2007. All patients received conventional myeloablative conditioning. T-replete grafts, and cyclosporine plus methotrexate-based GVHD prophylaxis. DNA-based HLA typing allowed categorization of 732 patients (25.3%) as positive and 2159 patients (74.7%) as negative for DRBI*15:01 or *15:02 (DR15). There were no significant differences in baseline characteristics between the HLA DR15 positive and negative groups. In univariate analysis, HLA-DR15 status had no impact on neutrophil engraftment, aGVHD, chronic GVHD (cGVHD), treatment-related mortality, relapse, disease-free survival, or overall survival (OS). In multivariate analysis, DR15 status showed no significant difference in aGVHD, cGVHD, OS, or relapse. In conclusion, DR15 status had no impact on major HLA-matched sibling donor hematopoietic cell transplant outcomes in this large and homogenous cohort of patients with leukemia and MDS. Biol Blood Marrow Transplant 18: 1302-1308 (2012) Published by Elsevier Inc on behalf of American Society for Blood and Mal-row Transplantation

引用

页码：1302 / 1308

页数：7

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