Construction of synthetic regulatory networks in yeast

被引：59

作者：

Blount, Benjamin A. ^{[1
,2
]}

Weenink, Tim ^{[2
]}

Ellis, Tom ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Synthet Biol & Innovat, London SW7 2AZ, England

来源：

FEBS LETTERS | 2012年 / 586卷 / 15期

基金：

英国工程与自然科学研究理事会;

关键词：

Yeast; Synthetic biology; Regulatory network; Saccharomyces cerevisiae; Regulation; Biological part; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE; RNA CONTROLLERS; PROTEIN; DNA; BIOLOGY; MODULES; SYSTEMS; DISRUPTION; SELECTION;

D O I：

10.1016/j.febslet.2012.01.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast species such as Saccharomyces cerevisiae have been exploited by humans for millennia and so it is therefore unsurprising that they are attractive cells to re-engineer for industrial use. Despite many beneficial traits yeast has for synthetic biology, it currently lags behind Escherichia coli in the number of synthetic networks that have been described. While the eukaryotic nature of yeast means that its regulation is not as simple to predict as it is for E. coli, once initial considerations have been made yeast is pleasingly tractable. In this review we provide a loose guide for constructing and implementing synthetic regulatory networks in S. cerevisiae using examples from previous research to highlight available resources, specific considerations and potential future advances. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2112 / 2121

页数：10

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