Association between plasma xanthine oxidoreductase activity and the renal function in a general Japanese population: The Tohoku Medical Megabank community-based cohort study

被引：4

作者：

Taguchi, Satoru ^{[1
,2
]}

Nasu, Takahito ^{[1
,2
,3
,7
]}

Satoh, Mamoru ^{[1
,3
]}

Kotozaki, Yuka ^{[3
]}

Tanno, Kozo ^{[3
,4
]}

Tanaka, Fumitaka ^{[3
,5
]}

Asahi, Koichi ^{[3
,5
]}

Ohmomo, Hideki ^{[1
,3
]}

Kikuchi, Hiroto ^{[1
,2
]}

Kobayashi, Takamasa ^{[2
]}

Morino, Yoshihiro ^{[2
]}

Shimizu, Atsushi ^{[1
,3
]}

Sobue, Kenji ^{[6
]}

Sasaki, Makoto ^{[3
]}

机构：

[1] Iwate Med Univ, Inst Biomed Sci, Dept Biomed Informat Anal, Morioka, Iwate, Japan

[2] Iwate Med Univ, Dept Internal Med, Div Cardiol, Morioka, Iwate, Japan

[3] Iwate Med Univ, Iwate Tohoku Med Megabank Org, Morioka, Iwate, Japan

[4] Iwate Med Univ, Dept Hyg & Prevent Med, Morioka, Iwate, Japan

[5] Iwate Med Univ, Dept Internal Med, Div Nephrol & Hypertens, Morioka, Iwate, Japan

[6] Iwate Med Univ, Inst Biomed Sci, Dept Neurosci, Morioka, Iwate, Japan

[7] Iwate Med Univ, Inst Biomed Sci, Dept Internal Med, Div Biomed Informat Anal,Div Cardiol, 2-1-1 Idaidori, Shiwa, Iwate 0283695, Japan

来源：

KIDNEY & BLOOD PRESSURE RESEARCH | 2022年 / 47卷 / 12期

关键词：

HIGHLY SENSITIVE ASSAY; OXIDATIVE STRESS; URIC-ACID; DISEASE; HEART; OXIDASE; PROTEIN;

D O I：

10.1159/000527654

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Introduction: Xanthine oxidoreductase (XOR) has been identified as a critical source of reactive oxygen species in various pathophysiological conditions, including hypertension, endothelial dysfunction and atherosclerosis. This study investigated the association between XOR and renal function in a general Japanese population.Methods: The Iwate Tohoku Medical Megabank Organization pooled individual participant data from a community-based cohort study in Iwate prefecture. Chronic kidney disease (CKD) was estimated using the estimated glomerular filtration rate of cystatin C (eGFRcys). Individuals with a history of hyperuricemia or severe renal dysfunction (eGFRcys < 15 ml/min/1.73 m2 or undergoing dialysis) were excluded from the study. We performed a multinominal multivariate logistic analysis adjusted for age, blood pressure, uric acid, glycated hemoglobin A1c, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol to associate XOR activity and renal function.Results: The present study included 4,248 participants (male/female: 1,373/2,875, age: 62.9 +/- 11.7 years). When participants were divided according to XOR quartiles, blood pressure, body mass index, uric acid, low-density lipoprotein cholesterol and glycated hemoglobin A1c were highest in the highest XOR quartile (all p < 0.001). The XOR activity was significantly higher in the subgroup with CKD stage G3 and G4 (G1 vs. G2 vs. G3-G4: 44.8 +/- 40.5 vs 52.0 +/- 42.9 vs. 54.1 +/- 43.9 pmol / h / mL, p = 0.02). The higher XOR activity was significantly associated with an increase of CKD stage: the odd ratios (95% confidence intervals) per 1 pmol/h/mL increase in XOR activity with CKD stage G1 as a reference were 1.37 (1.13-1.73) in G2 and 1.51 (1.30-1.84) in G3-G4. Conclusion: The present study concluded that high XOR activity was associated with the severity of CKD in a general Japanese population, suggesting that upregulated XOR activity may be involved in advanced renal dysfunction.

引用

页码：722 / 728

页数：7

共 32 条

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