Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

被引：35
作者：
Kemp-Harper, Barbara K. [1 ]
Horowitz, John D. [3 ]
Ritchie, Rebecca H. [2 ,4 ]
机构：
[1] Monash Univ, Biomed Discovery Inst, Dept Pharmacol, Cardiovasc Dis Program, Clayton, Vic, Australia
[2] Monash Univ, Dept Med, Clayton, Vic, Australia
[3] Univ Adelaide, Basil Hetzel Inst, Queen Elizabeth Hosp, Dept Cardiol, Woodville, SA, Australia
[4] Baker IDI Heart & Diabet Inst, Heart Failure Pharmacol, POB 6492, Melbourne, Vic 3004, Australia
来源：
DRUGS | 2016年 / 76卷 / 14期
关键词：
NO-CENTER-DOT; SOLUBLE GUANYLATE-CYCLASE; CARDIAC SARCOPLASMIC-RETICULUM; NITRIC-OXIDE; ANGELIS SALT; ISOPROPYLAMINE-NONOATE; IN-VIVO; RAT CARDIOMYOCYTES; POSITIVE INOTROPY; EUROPEAN-SOCIETY;
D O I：
10.1007/s40265-016-0631-y
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Heart failure (HF) is a major cause of hospital admission in the Western world, yet there remains a paucity of effective pharmacological management options. With the recent development of synthetic, next-generation nitroxyl (HNO) donors and their progress into clinical trials, it is timely to now provide an update on the therapeutic potential of HNO donors in the management of acute decompensated heart failure. In this article, we summarize current understanding of the pharmacology of HNO (in comparison with its redox sibling, nitric oxide), its spectrum of cardioprotective actions, and efforts to translate these into the clinic. Future research directions for this exciting new class of HF drugs are also considered.
引用
收藏
页码：1337 / 1348
页数：12
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