LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan

被引：107

作者：

Mellroth, Peter ^{[1
]}

Daniels, Robert ^{[2
]}

Eberhardt, Alice ^{[1
]}

Ronnlund, Daniel ^{[3
]}

Blom, Hans ^{[3
]}

Widengren, Jerker ^{[3
]}

Normark, Staffan ^{[1
]}

Henriques-Normark, Birgitta ^{[1
,4
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] Stockholm Univ, Dept Biochem & Biophys, Ctr Biomembrane Res, S-10691 Stockholm, Sweden

[3] Albanova Univ Ctr, Royal Inst Technol, Dept Appl Phys, S-10691 Stockholm, Sweden

[4] Karolinska Univ Hosp, Dept Lab Med, Div Clin Microbiol, S-17176 Stockholm, Sweden

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 14期

基金：

瑞典研究理事会;

关键词：

PENICILLIN RESISTANCE; PNEUMOCOCCAL AUTOLYSIN; RECOGNITION PROTEIN; SURFACE-PROTEINS; ENZYME-ACTIVITY; PNEUMOLYSIN; FRATRICIDE; VIRULENCE; GENE; ATTENUATION;

D O I：

10.1074/jbc.M111.318584

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The regulation of cell wall hydrolysis by the pneumococcal autolysin LytA is poorly understood. Results: The cell wall is susceptible to extracellular LytA only during the stationary phase or after cell wall synthesis inhibition. Conclusion: LytA is regulated on the substrate level, where peptidoglycan modifications likely prevent LytA hydrolysis. Significance: The control of amidases is essential for bacterial survival, cell-wall synthesis, and division.

引用

页码：11018 / 11029

页数：12

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