High Diagnostic Yield of Tuberculosis From Screening Urine Samples From HIV-Infected Patients With Advanced Immunodeficiency Using The Xpert MTB/RIF Assay

被引：47
作者：
Lawn, Stephen D. [1 ,2 ]
Kerkhoff, Andrew D. [1 ,3 ]
Vogt, Monica [1 ]
Wood, Robin [1 ]
机构：
[1] Univ Cape Town, Desmond Tutu HIV Ctr, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa
[2] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Clin Res, London WC1, England
[3] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2012年 / 60卷 / 03期
基金：
英国惠康基金; 美国国家卫生研究院;
关键词：
HIV; tuberculosis; screening; diagnosis; Africa; urine; Xpert MTB/RIF; antiretroviral; ANTIRETROVIRAL THERAPY; PULMONARY TUBERCULOSIS; RECORDING-SYSTEM; EARLY MORTALITY; LIPOARABINOMANNAN; ASSOCIATION; PREVALENCE; ACCURACY; OUTCOMES; PROGRAM;
D O I：
10.1097/QAI.0b013e318258c6af
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We determined the diagnostic yield of the Xpert MTB/RIF assay for tuberculosis (TB) when testing small volumes of urine from ambulatory HIV-infected patients before starting antiretroviral therapy in South Africa. Compared with a gold standard of sputum culture, the sensitivity of urine Xpert among those with CD4 cell counts of <50, 50-100, and >100 cells per microliter were 44.4%, 25.0%, and 2.7% (P = 0.001), respectively. Urine Xpert testing provides a means of rapid TB diagnosis in patients with advanced immunodeficiency and poor prognosis. These data are indicative of high rates of TB dissemination and renal involvement in this clinical population.
引用
收藏
页码：289 / 294
页数：6
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