Mechanisms of sex hormones in autoimmunity: focus on EAE

被引：26

作者：

Lasrado, Ninaad ^{[1
]}

Jia, Ting ^{[1
]}

Massilamany, Chandirasegaran ^{[2
]}

Franco, Rodrigo ^{[1
]}

Illes, Zsolt ^{[3
]}

Reddy, Jay ^{[1
]}

机构：

[1] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA

[2] CRISPR Therapeut, Cambridge, MA USA

[3] Univ Southern Denmark, Odense Univ Hosp, Dept Neurol, Odense, Denmark

来源：

BIOLOGY OF SEX DIFFERENCES | 2020年 / 11卷 / 01期

关键词：

Sex hormones; Autoimmunity; EAE; MS; T cells; ESTROGEN-RECEPTOR-ALPHA; REGULATORY T-CELLS; MULTIPLE-SCLEROSIS SUSCEPTIBILITY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; EPIDERMAL LANGERHANS CELLS; COLLAGEN-INDUCED ARTHRITIS; CROHNS-DISEASE IMPROVES; GENDER-DIFFERENCES; B-CELL; REPLACEMENT THERAPY;

D O I：

10.1186/s13293-020-00325-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sex-related differences in the occurrence of autoimmune diseases is well documented, with females showing a greater propensity to develop these diseases than their male counterparts. Sex hormones, namely dihydrotestosterone and estrogens, have been shown to ameliorate the severity of inflammatory diseases. Immunologically, the beneficial effects of sex hormones have been ascribed to the suppression of effector lymphocyte responses accompanied by immune deviation from pro-inflammatory to anti-inflammatory cytokine production. In this review, we present our view of the mechanisms of sex hormones that contribute to their ability to suppress autoimmune responses with an emphasis on the pathogenesis of experimental autoimmune encephalomyelitis.

引用

页数：14

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