Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation

被引:35
作者
Kiyici, M. [1 ]
Yilmaz, M. [1 ]
Akyildiz, M. [1 ]
Arikan, C. [1 ]
Aydin, U. [1 ]
Sigirli, D. [1 ]
Nart, D. [1 ]
Yilmaz, F. [1 ]
Ozacar, T. [1 ]
Karasu, Z. [1 ]
Kilic, M. [1 ]
机构
[1] Ege Univ, Fac Med, Organ Transplantat Ctr, TR-35100 Izmir, Turkey
关键词
D O I
10.1016/j.transproceed.2008.03.156
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background/Aims. Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) recurrences affect both patient and graft survivals post-orthotopic liver transplantation (OLT) in HBV patients with HCC. We analyzed the relationship between HBV and HCC recurrence in a large cohort of HBV-OLT patients with versus without HCC. Methods. Two hundred eighty-seven HBV patients with OLT (72 also with HCC) were included in the study. Mean follow-up in the post-OLT period was 31.7 +/- 24.7 (range, 3-119) months. Results. Post-OLT HBV recurrence observed in 10.1% of patients was more prevalent among the HCC group; 23.6% versus 5.5% in patients with and without HCC, respectively. The mean interval for the development of HBV recurrence was 39.5 +/- 28.5 (range, 2-99) months. Among 72 HCC patients, 8 patients (11.1%) had recurrent HCC, and 7 of them also had HBV recurrence. The mean interval for the development of HCC recurrence was 11.2 +/- 7.85 (range, 2-23) months after OLT. OLT patients with HCC with tumors exceeding the Milan criteria had worse 1-, 3-, and 5-year survival rates than patients with HCC meeting the Milan criteria. HBV and HCC recurrence-free survivals were significantly lower in patients with HCC and HBV recurrence, respectively. In the 7 patients with both HCC and HBV recurrence, mean HBV recurrence time was 9.42 +/- 6.75 months and mean HCC recurrence time was 9.57 +/- 6.75 months. There was a strong correlation between HBV and HCC recurrence times. Cox proportional hazards regression analysis showed that only HCC recurrence was a significant independent predictor of HBV recurrence (P < .001; hazard ratio [HR] = 26.94; 95% confidence interval [CI] = 10.81-67.11). On the other hand, HBV recurrence (P = .013; HR = 5.80; 95% CI = 1.45-23.17) and nodule count (P = .014; HR = 13.08; 95% CI = 1.70-100.83) were significant predictors of HCC recurrence. Conclusions. HBV and HCC recurrences demonstrate a close relationship in patients with OLT.
引用
收藏
页码:1511 / 1517
页数:7
相关论文
共 50 条
[31]   Predictors of survival in patients undergoing liver transplantation for hepatocellular carcinoma [J].
Deenadayalu, VP ;
Tector, AJ ;
Agarwal, D ;
Lumeng, L ;
Chalasani, N ;
Liangpunsakul, S ;
Fridell, J ;
Vianna, RM ;
Qi, R ;
Kwo, PY .
GASTROENTEROLOGY, 2005, 128 (04) :A758-A758
[32]   Intrahepatic cholangiocarcinoma in patients undergoing liver transplantation for hepatocellular carcinoma [J].
Dayangac, M. ;
Bozkurt, B. ;
Gurcan, Inan N. ;
Dogusoy, Bulbul G. ;
Tokat, Y. .
TRANSPLANTATION, 2018, 102 :275-276
[33]   The Association Between Hepatitis B Virus Mutations and the Risk of Liver Disease and Hepatocellular Carcinoma [J].
Akrami, Hassan ;
Monjezi, Mohammad Rafiee ;
Ilbeigi, Shahrzad ;
Amiri, Farshid ;
Fattahi, Mohammad Reza .
CURRENT MOLECULAR MEDICINE, 2022, 22 (06) :514-523
[34]   Predicting Outcomes of Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma [J].
Firl, Daniel J. ;
Sasaki, Kazunari ;
Aucejo, Federico N. .
GASTROENTEROLOGY, 2018, 154 (06) :1856-1857
[35]   Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation [J].
Salman, Ahmed ;
Aon, Mohamed ;
Hussein, Amr ;
Salman, Mohamed ;
Tourky, Mohamed ;
Mahmoud, Ahmed ;
Aljarad, Feras ;
Elkaseer, Mohamed ;
Shaaban, Hossam El-Din ;
Moustafa, Ahmed ;
El-Mikkawy, Ahmed ;
Gaballa, Nahla ;
Abdallah, Heba ;
Rashed, Zaky Ftouh Zaky ;
Elkassar, Hesham .
INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 :5711-5718
[36]   Preoperative Prediction of Tumor Recurrence and Survival in Patients Undergoing Living Liver Transplantation for Hepatocellular Carcinoma. [J].
Fujiyoshi, Masato ;
Shimamura, Tsuyoshi ;
Todo, Satoru .
LIVER TRANSPLANTATION, 2013, 19 :S293-S293
[37]   IMPACT OF BRIDGING THERAPY ON TUMOR RECURRENCE AND SURVIVAL IN PATIENTS UNDERGOING LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA (HCC) [J].
Hassett, Molly ;
Mantry, Parvez S. ;
Mejia, Alejandro ;
Weinstein, Jeffrey S. ;
Mubarak, Abdullah ;
Madani, Bahar ;
Cheng, Stephen ;
Anthony, Tiffany .
HEPATOLOGY, 2011, 54 :647A-647A
[38]   Association Between Nucleoside Analogues and Risk of Hepatitis B Virus-Related Hepatocellular Carcinoma Recurrence Following Liver Resection [J].
Wu, Chun-Ying ;
Chen, Yi-Ju ;
Ho, Hsiu J. ;
Hsu, Yao-Chun ;
Kuo, Ken N. ;
Wu, Ming-Shiang ;
Lin, Jaw-Town .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (18) :1906-1913
[39]   Time interval to recurrence as a predictor of overall survival in salvage liver transplantation for patients with hepatocellular carcinoma associated with hepatitis B virus [J].
Hu, Zhenhua ;
Zhou, Jie ;
Li, Zhiwei ;
Xiang, Jie ;
Qian, Ze ;
Wu, Jian ;
Zhang, Min ;
Zheng, Shusen .
SURGERY, 2015, 157 (02) :239-248
[40]   Liver Fibrosis in Patients With Hepatocellular Carcinoma: Comparison Between Hepatitis B and C [J].
Yang, Ju Dong ;
Roberts, Lewis R. ;
Kim, Hyung Joon ;
Kim, Bohyun ;
Benson, Joanne T. ;
Pedersen, Rachel A. ;
Mettler, Teresa A. ;
Therneau, Terry M. ;
Sanderson, Schuyler ;
Kim, W. Ray .
GASTROENTEROLOGY, 2010, 138 (05) :S813-S813