Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer

被引：35

作者：

Geis, Christian ^{[1
]}

Gruenewald, Benedikt ^{[1
]}

Weishaupt, Andreas ^{[1
]}

Wultsch, Thomas ^{[2
]}

Toyka, Klaus V. ^{[1
]}

Reif, Andreas ^{[2
]}

Sommer, Claudia ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany

[2] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 08期

关键词：

Anti-amphiphysin antibodies; Anxiety; Stiff person syndrome; Amygdala; Passive transfer; STIFF-PERSON SYNDROME; AUTOANTIBODIES; ANTIBODIES;

D O I：

10.1007/s00702-012-0773-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.

引用

页码：981 / 985

页数：5

共 18 条

[11] Encephalitis and antibodies to synaptic and neuronal cell surface proteins [J].

Lancaster, Eric ;

Martinez-Hernandez, Eugenia ;

Dalmau, Josep .

NEUROLOGY, 2011, 77 (02) :179-189

[12] AUTOANTIBODIES TO GABAERGIC NEURONS AND PANCREATIC BETA-CELLS IN STIFF-MAN SYNDROME [J].

SOLIMENA, M ;

FOLLI, F ;

APARISI, R ;

POZZA, G ;

DECAMILLI, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (22) :1555-1560

[13] Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin [J].

Sommer, C ;

Weishaupt, A ;

Brinkhoff, J ;

Biko, L ;

Wessig, C ;

Gold, R ;

Toyka, KV .

LANCET, 2005, 365 (9468) :1406-1411

[14] Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes [J].

Stich, Oliver ;

Jarius, Sven ;

Kleer, Barbara ;

Rasiah, Christiane ;

Voltz, Raymond ;

Rauer, Sebastian .

JOURNAL OF NEUROIMMUNOLOGY, 2007, 183 (1-2) :220-224

[15] Autoantibodies associated with diseases of the CNS: new developments and future challenges [J].

Vincent, Angela ;

Bien, Christian G. ;

Irani, Sarosh R. ;

Waters, Patrick .

LANCET NEUROLOGY, 2011, 10 (08) :759-772

[16] Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndrome [J].

Wessig, C ;

Klein, R ;

Schneider, MF ;

Toyka, KV ;

Naumann, M ;

Sommer, C .

NEUROLOGY, 2003, 61 (02) :195-198

[17]

Wultsch T, 2007, J NEURAL TRANSM-SUPP, P69

[18] CHRONIC CATHETERIZATION OF SPINAL SUBARACHNOID SPACE [J].

YAKSH, TL ;

RUDY, TA .

PHYSIOLOGY & BEHAVIOR, 1976, 17 (06) :1031-1036

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