Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer

被引：35

作者：

Geis, Christian ^{[1
]}

Gruenewald, Benedikt ^{[1
]}

Weishaupt, Andreas ^{[1
]}

Wultsch, Thomas ^{[2
]}

Toyka, Klaus V. ^{[1
]}

Reif, Andreas ^{[2
]}

Sommer, Claudia ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany

[2] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 08期

关键词：

Anti-amphiphysin antibodies; Anxiety; Stiff person syndrome; Amygdala; Passive transfer; STIFF-PERSON SYNDROME; AUTOANTIBODIES; ANTIBODIES;

D O I：

10.1007/s00702-012-0773-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.

引用

页码：981 / 985

页数：5

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