Cabraleadiol monoacetate, atranorin, methyl-beta-orcinolcarboxylate, zeorin, 4- O-methylcryptochlorophaeic acid, and lichexanthone were isolated from the lichen Pyxine consocians Vainio . Heterodermia leucomelos (L). Poelt contained a new triterpenoid, 6 alpha-hydroxyhop-21 beta H-22(29)-en, along with atranorin, zeorin, glyceryl trilinolate, and 3,6-dimethyl-2-hydroxy-4-methoxybenzoic acid. Cabraleadiol monoacetate, 4-O-methylcryptochlorophaeic acid, lichexanthone, and 3,6-dimethyl-2-hydroxy-4-methoxybenzoic acid showed mosquito larvicidal activity against the second instar larvae of Aedes aegypti . Lichexanthone exhibited human sperm motility enhancing activity.