Thermally Switched Release from Nanoparticle Colloidosomes

被引:50
作者
Zhou, Shaobing [1 ]
Fan, Jing [2 ,3 ]
Datta, Sujit S. [2 ,3 ]
Guo, Ming [2 ,3 ]
Guo, Xing [1 ]
Weitz, David A. [2 ,3 ]
机构
[1] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Peoples R China
[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
colloidosomes; release; copolymers; microfluidics; encapsulation; EMULSIONS; PARTICLES;
D O I
10.1002/adfm.201301030
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanoparticle colloidosomes, whose release can be switched on and off in response to a temperature change, are fabricated. Unlike in other systems, the switchable release does not require the colloidosome shell to deform; it instead occurs due to the adsorption or desorption of a block copolymer, dissolved in the core, at the inner surface of the colloidosome shell, concomitantly blocking or unblocking the pores in the shell. The colloidosomes are prepared using double emulsion templates produced by microfluidics, and are thus highly monodisperse; moreover, they are mechanically stable and consist of biocompatible components, making them suitable for the encapsulation, delivery, and release of a broad range of active materials.
引用
收藏
页码:5925 / 5929
页数:5
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