Functions of RNA N6-methyladenosine modification in cancer progression

被引：24
|
作者：
Chen, Bing [1 ]
Li, Ya [1 ]
Song, Ruifeng [1 ]
Xue, Chen [2 ]
Xu, Feng [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Jianshe Eastern Rd, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Infect Dis, 1 Jianshe Eastern Rd, Zhengzhou 450052, Henan, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2019年 / 46卷 / 01期
基金：
中国国家自然科学基金;
关键词：
RNA N6-methyladenosine modification; Cancer progression; Physiological and pathological processes; Detection approaches; Clinical application; SINGLE-NUCLEOTIDE-RESOLUTION; MESSENGER-RNA; M(6)A RNA; N-6-METHYLADENOSINE RNA; STRUCTURAL BASIS; YTH DOMAIN; NUCLEAR-RNA; METHYLATION; DEMETHYLASE; RECOGNITION;
D O I：
10.1007/s11033-018-4471-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.
引用
收藏
页码：1383 / 1391
页数：9
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