Functions of RNA N6-methyladenosine modification in cancer progression

被引：24
|
作者：
Chen, Bing [1 ]
Li, Ya [1 ]
Song, Ruifeng [1 ]
Xue, Chen [2 ]
Xu, Feng [1 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Gastroenterol, 1 Jianshe Eastern Rd, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Infect Dis, 1 Jianshe Eastern Rd, Zhengzhou 450052, Henan, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2019年 / 46卷 / 01期
基金：
中国国家自然科学基金;
关键词：
RNA N6-methyladenosine modification; Cancer progression; Physiological and pathological processes; Detection approaches; Clinical application; SINGLE-NUCLEOTIDE-RESOLUTION; MESSENGER-RNA; M(6)A RNA; N-6-METHYLADENOSINE RNA; STRUCTURAL BASIS; YTH DOMAIN; NUCLEAR-RNA; METHYLATION; DEMETHYLASE; RECOGNITION;
D O I：
10.1007/s11033-018-4471-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.
引用
收藏
页码：1383 / 1391
页数：9
相关论文
共 50 条
  • [21] Novel Insights Into the Role of N6-Methyladenosine RNA Modification in Bone Pathophysiology
    Chen, Junbo
    Tian, Yihong
    Zhang, Qi
    Ren, Dapeng
    Zhang, Qiang
    Yan, Xiao
    Wang, Lingzhi
    He, Zijing
    Zhang, Wei
    Zhang, Tianzhen
    Yuan, Xiao
    STEM CELLS AND DEVELOPMENT, 2021, 30 (01) : 17 - 28
  • [22] N6-methyladenosine (m6A) RNA modification in human cancer
    Huo, Fu-Chun
    Zhu, Zhi-Man
    Pei, Dong-Sheng
    CELL PROLIFERATION, 2020, 53 (11)
  • [23] N6-methyladenosine modification in ischemic stroke: Functions, regulation, and therapeutic potential
    Han, Fei
    HELIYON, 2024, 10 (03)
  • [24] Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification
    Wang, Yushuai
    Huang, Huilin
    Chen, Jianjun
    Weng, Hengyou
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2024, 86
  • [25] Function and evolution of RNA N6-methyladenosine modification
    Zhu, Zhi-Man
    Huo, Fu-Chun
    Pei, Dong-Sheng
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (11): : 1929 - 1940
  • [26] The N6-Methyladenosine RNA modification in pluripotency and reprogramming
    Aguilo, Francesca
    Walsh, Martin J.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2017, 46 : 77 - 82
  • [27] Mechanism of N6-methyladenosine modification and its emerging role in cancer
    Zhang, Sicong
    PHARMACOLOGY & THERAPEUTICS, 2018, 189 : 173 - 183
  • [28] Novel Insights Into the Multifaceted Functions of RNA n6-Methyladenosine Modification in Degenerative Musculoskeletal Diseases
    Li, Hengzhen
    Xiao, WenFeng
    He, Yuqiong
    Wen, Zeqin
    Cheng, Siyuan
    Zhang, Yi
    Li, Yusheng
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [29] Mechanism of RNA modification N6-methyladenosine in human cancer
    Zhou, Zijian
    Lv, Jiancheng
    Yu, Hao
    Han, Jie
    Yang, Xiao
    Feng, Dexiang
    Wu, Qikai
    Yuan, Baorui
    Lu, Qiang
    Yang, Haiwei
    MOLECULAR CANCER, 2020, 19 (01)
  • [30] The potential role of RNA N6-methyladenosine in Cancer progression
    Tianyi Wang
    Shan Kong
    Mei Tao
    Shaoqing Ju
    Molecular Cancer, 19
12345