Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications

被引：133

作者：

Ding, Lang ^{[1
,2
]}

Shan, Xindi ^{[1
,2
]}

Zhao, Xiaoliang ^{[1
,2
]}

Zha, Hualian ^{[1
,2
]}

Chen, Xiaoyu ^{[1
,2
]}

Wang, Jianjun ^{[1
,2
]}

Cai, Chao ^{[1
,2
,3
]}

Wang, Xiaojiang ^{[1
,2
]}

Li, Guoyun ^{[1
,2
]}

Hao, Jiejie ^{[1
,2
]}

Yu, Guangli ^{[1
,2
,3
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Qingdao 266003, Peoples R China

[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266003, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2017年 / 157卷

基金：

中国博士后科学基金;

关键词：

Chitosan; Silver nanoparticles; Bletilla striata polysaccharide; Bilayer; Wound healing; SILVER NANOPARTICLES; IN-VITRO; HYDROGEL; GENIPIN; ALGINATE; GENOTOXICITY; CYTOTOXICITY; FABRICATION; BACTERIA; DELIVERY;

D O I：

10.1016/j.carbpol.2016.11.040

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The purpose of this study was to develop a promising wound dressing. Though chitosan cross-linked with genipin has been widely used as biomaterials, with the addition of partially oxidized Bletilla striata polysaccharide, the newly developed material in this study (coded as CSGB) showed less gelling time, more uniform aperture distribution, higher water retention, demanded mechanical strength and more L929 cell proliferation compared to the chitosan cross-linked only with genipin. Owning to partial blocking of free amino groups of chitosan, CSGB revealed almost no antibacterial activities, thus the bilayer composite of chitosan-silver nanoparticles (CS-AgG) on CSGB was designed to inhibit microbial invasion. The in vivo studies indicated that both CSGB and bilayer wound dressing significantly accelerated the healing rate of cutaneous wounds in mice, and the bilayer exhibited better mature epidermization with less inflammatory cells on Day 7. Therefore, this novel bilayer composite has great potential in wound dressing applications. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1538 / 1547

页数：10

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