The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

被引:493
作者
Morrison, Deborah K. [1 ]
机构
[1] NCI Frederick, Lab Cell & Dev Signaling, Frederick, MD 21702 USA
关键词
ORGAN SIZE CONTROL; HIPPO PATHWAY; JNK PHOSPHORYLATION; CONTACT INHIBITION; GROWTH-CONTROL; GENE-PRODUCT; DNA-DAMAGE; B-RAF; MTOR; TSC2;
D O I
10.1016/j.tcb.2008.10.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phosphoserine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phosphoregulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.
引用
收藏
页码:16 / 23
页数:8
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