RELL1, a novel oncogene, accelerates tumor progression and regulates immune infiltrates in glioma

被引：18
作者：
Jin, Xiaohong [1 ]
Xie, Huiwen [1 ]
Liu, Xiaoman [1 ]
Shen, Qiuyan [2 ]
Wang, Ziheng [3 ,4 ]
Hao, Haiyan [5 ]
Gu, Yan [1 ]
机构：
[1] Nantong Univ, Dept Canc Chemotherapy, Affiliated Hosp, Nantong 226000, Jiangsu, Peoples R China
[2] Anhui Med Univ, Hosp Joint Logist Support Force PLA 904, Dept Neurosurg, Wuxi Clin Coll, Wuxi 214044, Jiangsu, Peoples R China
[3] Nantong Univ, Dept Clin Biobank, Affiliated Hosp, Nantong 226000, Jiangsu, Peoples R China
[4] Nantong Univ, Dept Neurosurg, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China
[5] Nantong Univ, Dept Outpatients, Affiliated Hosp, Nantong 226000, Jiangsu, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 87卷
关键词：
Glioma; CGGA; TCGA; RELL1; NK cells;
D O I：
10.1016/j.intimp.2020.106707
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Diffuse gliomas are the most prevalent primary brain tumors. The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases provide evidence of the relationships between gliomas and altered molecular pathways. In glioma pathogenesis, the microenvironment has emerged as a potential indicator of tumor progression. Methods: We investigated and confirmed the role of RELT-like 1 (RELL1) oncogene in glioblastoma and low-grade glioma by data mining large cohorts of TCGA and the CGGA. Correlations between immune cells and RELL1 were verified using the CIBERSORT algorithm. Results: Our analysis revealed that RELL1 expression was much higher in grade-dependent glioma patients with poor prognosis. Comparable prognostic values for isocitrate dehydrogenase 1 (IDH1) and RELL1 were observed during in-depth analyses of the integrated correlations. Moreover, RELL1 was found to be associated with numerous tumor-infiltrating immune cells in glioma-affected patients. Conclusion: We conclude that RELL1 might serve as a potential therapeutic target or prognostic marker in glioblastoma and diffuse glioma cases.
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页数：8
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