Bilateral Facial Nerve Palsy Due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody

被引：12

作者：

Mori, Akio ^{[1
]}

Hira, Ken-ichiro ^{[3
]}

Hatano, Taku ^{[1
]}

Okuma, Yasuyuki ^{[3
]}

Kubo, Shin-ichiro ^{[1
]}

Hirano, Kazuoki ^{[3
]}

Ohno, Kana ^{[1
]}

Noda, Kazuyuki ^{[3
]}

Suzuki, Hitoshi ^{[2
]}

Ohsawa, Isao ^{[2
]}

Hattori, Nobutaka

机构：

[1] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Dept Nephrol, Tokyo 1138421, Japan

[3] Juntendo Shizuoka Hosp, Dept Neurol, Tokyo, Japan

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2013年 / 346卷 / 03期

关键词：

Myeloperoxidase-antineutrophil cytoplasmic antibody-related vasculitis; Facial nerve neuropathy; Otitis media; Trigeminal neuropathy; Cranial polyneuropathy; Pachymeningitis; ANCA-ASSOCIATED VASCULITIDES; WEGENER GRANULOMATOSIS; PATHOGENESIS;

D O I：

10.1097/MAJ.0b013e318288371f

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Otitis media (OM) is well known as a common feature of proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA)-related Wegener granulomatosis, but is a very rare condition in myeloperoxidase ANCA (MPO-ANCA)-related vasculitis. In addition, there have been a few reports showing an association of MPO-ANCA-positive OM with cranial polyneuropathy. In this report, we describe 2 patients with bilateral facial nerve palsy due to MPO-ANCA-related OM. One patient also had bilateral trigeminal neuropathy, pachymeningitis and MPO-ANCA-related glomerulonephritis, whereas the other showed isolated bilateral facial nerve palsy with OM. In both the patients, treatment with prednisolone and immune-suppressant drugs resulted in an improvement of OM and cranial polyneuropathy. Physicians should be aware that MPO-ANCA-positive OM can cause bilateral facial nerve palsy.

引用

页码：240 / 243

页数：4

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