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The chromosome replication machinery of the archaeon Sulfolobus solfataricus
被引:31
作者:

Duggin, Iain G.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Hutchinson Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England MRC, Hutchinson Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England

Bell, Stephen D.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Hutchinson Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England MRC, Hutchinson Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England
机构:
[1] MRC, Hutchinson Res Ctr, Canc Cell Unit, Cambridge CB2 2XZ, England
关键词:
D O I:
10.1074/jbc.R500029200
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In the three domains of life, the archaea, bacteria, and eukarya, there are two general lineages of DNA replication proteins: the bacterial and the eukaryal/archaeal lineages. The hyperthermophilic archaeon Sulfolobus solfataricus provides an attractive model for biochemical study of DNA replication. Its relative simplicity in both genomic and biochemical contexts, together with high protein thermostability, has already provided insight into the function of the more complex yet homologous molecules of the eukaryotic domain. Here, we provide an overview of recent insights into the functioning of the chromosome replication machinery of S. solfataricus, focusing on some of the relatively well characterized core components that act at the DNA replication fork.
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页码:15029 / 15032
页数:4
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