Effect of Perilla frutescens Fixed Oil on Experimental Esophagitis in Albino Wistar Rats

被引：17

作者：

Arya, Ekta ^{[1
]}

Saha, Sudipta ^{[1
]}

Saraf, Shubhini A. ^{[1
]}

Kaithwas, Gaurav ^{[1
]}

机构：

[1] Babasaheb Bhimrao Ambedkar Univ Cent Univ, Dept Pharmaceut Sci, Lucknow 226025, Uttar Pradesh, India

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

GASTROESOPHAGEAL-REFLUX DISEASE; ACIDS; PATHOGENESIS; MELATONIN; ILEUM;

D O I：

10.1155/2013/981372

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present study was undertaken to elucidate the effect of Perilla frutescens fixed oil on experimental esophagitis in albino rats. A group of rats (n = 6), treated with control vehicle (0.9% NaCl in double distilled water, 3 mL/kg, i.p.) and Perilla frutescens fixed oil (100%) (1, 2, and 3 mL/kg, i.p.), or pantoprazole (30 mg/kg, i.p.), were subjected to pylorus and forestomach ligation. Animals were sacrificed after 6 h and evaluated for the gastric pH, volume of gastric juices, total acidity, esophagitis index and free acidity. Esophageal tissues were further subjected to estimations of TBARS, GSH, catalase, and SOD. Treatment with fixed oil significantly inhibited the gastric secretion, total acidity, and esophagitis index. The oil also helped to restore the altered levels of oxidative stress parameters to normal. The present study also makes evident the in vitro antihistaminic and anticholinergic activity of alpha linolenic acid (ALA) (18 : 3, n - 3) on isolated rat ileum preparation. The lipoxygenase inhibitory, histamine antagonistic, antisecretory (anticholinergic), and antioxidant activity of the oil was attributed for its efficacy in reflux esophagitis.

引用

页数：6

共 26 条

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