Proteomic Study of Blood Serum in Coronary Atherosclerosis

被引：2
|
作者：
Stakhneva, E. M. [1 ]
Meshcheryakova, I. A. [2 ]
Demidov, E. A. [2 ]
Starostin, K. V. [2 ]
Ragino, Yu. I. [1 ]
Peltek, S. E. [2 ]
Voevoda, M. I. [1 ]
机构：
[1] Russian Acad Sci, Res Inst Internal & Prevent Med, Siberian Div, Novosibirsk, Russia
[2] Russian Acad Sci, Fed Res Ctr Inst Cytol & Genet, Siberian Div, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 03期
关键词：
ceruloplasmin; complement system; mass spectrometry; 2D-electrophoresis; coronary atherosclerosis; HEART-FAILURE; CERULOPLASMIN;
D O I：
10.1007/s10517-017-3611-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in protein level were determined. In blood serum of patients with coronary atherosclerosis, the content of C4 complement protein increased and ceruloplasmin level decreased, which is typical of heart failure and coronary heart disease.
引用
收藏
页码：343 / 345
页数：3
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