Elevated CA-125 in IgG4 mesenteritis: a red herring or a disease biomarker? Case report and literature review

被引：6

作者：

Maturana, Mailis Michaud ^{[1
]}

Panayotidis, Ismini ^{[1
]}

Psarelis, Savvas ^{[2
,3
]}

Nakos, George ^{[4
]}

Nikiphorou, Elena ^{[5
,6
]}

机构：

[1] UCL, Med Sch, London, England

[2] Nicosia Gen Hosp, Rheumatol Dept, Old Rd 215, CY-2029 Nicosia, Cyprus

[3] Univ Cyprus, Med Sch, Nicosia, Cyprus

[4] Nicosia Gen Hosp, Histopathol Dept, Nicosia, Cyprus

[5] Kings Coll London, Dept Acad Rheumatol, London, England

[6] Kings Coll London, Fac Life Sci & Med, Sch Immunol & Microbial Sci, Dept Inflammat Biol, London, England

来源：

RHEUMATOLOGY INTERNATIONAL | 2019年 / 39卷 / 07期

关键词：

Panniculitis; peritoneal; CA-125; antigen; Mesentery; Peritoneum; Inflammation; Immunoglobulin G; Biomarkers; tumor; SERUM CA-125; BENIGN;

D O I：

10.1007/s00296-018-4145-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenteric panniculitis (MP) is a rare chronic disease characterized by inflammation and subsequently fibrosis of adipose tissue of the omentum. Only recently it has been associated with IgG4-related disease. Cancer antigen 125 (CA-125) is a high-molecular mass glycoprotein, traditionally associated with ovarian cancer, although it can be elevated in other conditions. Herein we describe a case of a 56-year-old man with IgG4 related mesenteric panniculitis associated with very high levels of CA-125 at the onset of disease. The CA-125 levels corresponded to clinical disease activity and improved with steroid therapy and rituximab. A literature review was performed concerning possible association of MP, IgG4-related disease and CA-125. The review of literature suggests that high levels of CA-125 can be raised in non-malignant, inflammatory conditions including IgG4-related mesenteritis and can improve with treatment.

引用

页码：1285 / 1289

页数：5

共 20 条

[1]

Buyukbayrak EE, 2011, GYNAECOL OBSTET REPR, V17, P126

[2] Regional portal hypertension, systemic lymphadenopathy, and splenomegaly associated with autoimmune pancreatitis [J].