The disparate origins of ovarian cancers: pathogenesis and prevention strategies

被引：228

作者：

Karnezis, Anthony N. ^{[1
]}

Cho, Kathleen R. ^{[2
]}

Gilks, C. Blake ^{[1
]}

Pearce, Celeste Leigh ^{[3
]}

Huntsman, David G. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SMALL-CELL-CARCINOMA; GRADE-SEROUS-CARCINOMA; PROPHYLACTIC OOPHORECTOMY SPECIMENS; TUBAL INTRAEPITHELIAL CARCINOMA; TRANSCRIPTION FACTOR FOXL2; DICER1 HOTSPOT MUTATIONS; IIIB DOMAIN MUTATIONS; FALLOPIAN-TUBE; HYPERCALCEMIC TYPE; DELAYED OOPHORECTOMY;

D O I：

10.1038/nrc.2016.113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

引用

页码：65 / 74

页数：10

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