The disparate origins of ovarian cancers: pathogenesis and prevention strategies

被引：224
作者：
Karnezis, Anthony N. [1 ]
Cho, Kathleen R. [2 ]
Gilks, C. Blake [1 ]
Pearce, Celeste Leigh [3 ]
Huntsman, David G. [1 ]
机构：
[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada
[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
来源：
NATURE REVIEWS CANCER | 2017年 / 17卷 / 01期
基金：
美国国家卫生研究院;
关键词：
SMALL-CELL-CARCINOMA; GRADE-SEROUS-CARCINOMA; PROPHYLACTIC OOPHORECTOMY SPECIMENS; TUBAL INTRAEPITHELIAL CARCINOMA; TRANSCRIPTION FACTOR FOXL2; DICER1 HOTSPOT MUTATIONS; IIIB DOMAIN MUTATIONS; FALLOPIAN-TUBE; HYPERCALCEMIC TYPE; DELAYED OOPHORECTOMY;
D O I：
10.1038/nrc.2016.113
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.
引用
收藏
页码：65 / 74
页数：10
相关论文
共 162 条
  • [1] SMARCA4-deficient undifferentiated carcinoma of the ovary (small cell carcinoma, hypercalcemic type): clinicopathologic and immunohistochemical study of 3 cases
    Agaimy, Abbas
    Thiel, Falk
    Hartmann, Arndt
    Fukunaga, Masaharu
    [J]. ANNALS OF DIAGNOSTIC PATHOLOGY, 2015, 19 (05) : 283 - 287
  • [2] FOXL2 Is a Sensitive and Specific Marker for Sex Cord-Stromal Tumors of the Ovary
    Al-Agha, Osama M.
    Huwait, Hassan F.
    Chow, Christine
    Yang, Winnie
    Senz, Janine
    Kalloger, Steve E.
    Huntsman, David G.
    Young, Robert H.
    Gilks, C. Blake
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2011, 35 (04) : 484 - 494
  • [3] Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage
    Anglesio, M. S.
    Wang, Y.
    Yang, W.
    Senz, J.
    Wan, A.
    Heravi-Moussavi, A.
    Salamanca, C.
    Maines-Bandiera, S.
    Huntsman, D. G.
    Morin, G. B.
    [J]. JOURNAL OF PATHOLOGY, 2013, 229 (03) : 400 - 409
  • [4] Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality
    Anglesio, Michael S.
    Wang, Yi Kan
    Maassen, Madlen
    Horlings, Hugo M.
    Bashashati, Ali
    Senz, Janine
    Mackenzie, Robertson
    Grewal, Diljot S.
    Li-Chang, Hector
    Karnezis, Anthony N.
    Sheffield, Brandon S.
    McConechy, Melissa K.
    Kommoss, Friedrich
    Taran, Florin A.
    Staebler, Annette
    Shah, Sohrab P.
    Wallwiener, Diethelm
    Brucker, Sara
    Gilks, C. Blake
    Kommoss, Stefan
    Huntsman, David G.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (06):
  • [5] Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
    Anglesio, Michael S.
    Bashashati, Ali
    Wang, Yi Kan
    Senz, Janine
    Ha, Gavin
    Yang, Winnie
    Aniba, Mohamed R.
    Prentice, Leah M.
    Farahani, Hossein
    Chang, Hector Li
    Karnezis, Anthony N.
    Marra, Marco A.
    Yong, Paul J.
    Hirst, Martin
    Gilks, Blake
    Shah, Sohrab P.
    Huntsman, David G.
    [J]. JOURNAL OF PATHOLOGY, 2015, 236 (02) : 201 - 209
  • [6] [Anonymous], 1987, NEW ENGL J MED, V316, P650
  • [7] Reproductive and Hormonal Factors, and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Results from the International BRCA1/2 Carrier Cohort Study
    Antoniou, Antonis C.
    Rookus, Matti
    Andrieu, Nadine
    Brohet, Richard
    Chang-Claude, Jenny
    Peock, Susan
    Cook, Margaret
    Evans, D. Gareth
    Eeles, Rosalind
    Nogues, Catherine
    Faivre, Laurence
    Gesta, Paul
    van Leeuwen, Flora E.
    Ausems, Margreet G. E. M.
    Sorio, Ana
    Caldes, Trinidad
    Simard, Jacques
    Lubinski, Jan
    Gerdes, Anne-Marie
    Olah, Edith
    Fuerhauser, Christine
    Olsson, Hakan
    Arver, Brita
    Radice, Paolo
    Easton, Douglas F.
    Goldgarl, David E.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (02) : 601 - 610
  • [8] Characterization of the Immune Cell Repertoire in the Normal Fallopian Tube
    Ardighieri, Laura
    Lonardi, Silvia
    Moratto, Daniele
    Facchetti, Fabio
    Shih, Ie-Ming
    Vermi, William
    Kurman, Robert J.
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2014, 33 (06) : 581 - 591
  • [9] The Stem-Cell Profile of Ovarian Surface Epithelium is Reproduced in the Oviductal Fimbriae, with Increased Stem-Cell Marker Density in Distal Parts of the Fimbriae
    Auersperg, Nelly
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2013, 32 (05) : 444 - 453
  • [10] The Origin of Ovarian Carcinomas: A Unifying Hypothesis
    Auersperg, Nelly
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2011, 30 (01) : 12 - 21
12345678910