The Therapeutic Potential of Apigenin

被引：834

作者：

Salehi, Bahare ^{[1
]}

Venditti, Alessandro ^{[2
]}

Sharifi-Rad, Mehdi ^{[3
]}

Kregiel, Dorota ^{[4
]}

Sharifi-Rad, Javad ^{[5
]}

Durazzo, Alessandra ^{[6
]}

Lucarini, Massimo ^{[6
]}

Santini, Antonello ^{[7
]}

Souto, Eliana B. ^{[8
,9
]}

Novellino, Ettore ^{[7
]}

Antolak, Hubert ^{[4
]}

Azzini, Elena ^{[6
]}

Setzer, William N. ^{[10
]}

Martins, Natalia ^{[11
,12
]}

机构：

[1] Bam Univ Med Sci, Sch Med, Student Res Comm, Bam 44340847, Iran

[2] Sapienza Univ Roma, Dipartimento Chim, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[3] Zabol Univ Med Sci, Dept Med Parasitol, Zabol 61663335, Iran

[4] Lodz Univ Technol, Inst Fermentat Technol & Microbiol, Wolczanska 171-173, PL-90924 Lodz, Poland

[5] Semnan Univ Med Sci, Food Safety Res Ctr Salt, Semnan 3519899951, Iran

[6] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy

[7] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[8] Univ Coimbra Azinhaga Santa Comba, Fac Pharm, Polo Saude 3, P-3000548 Coimbra, Portugal

[9] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal

[10] Univ Alabama, Dept Chem, Huntsville, AL 35899 USA

[11] Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[12] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 06期

关键词：

apigenin; flavonoids; chronic diseases; diabetes; cancer; IN-VITRO EVALUATION; CELL-CYCLE ARREST; NF-KAPPA-B; MONOAMINE-OXIDASE; DIETARY FLAVONOIDS; PROMISING THERAPEUTICS; PHYTOCHEMICAL ANALYSIS; SOLID DISPERSIONS; OXIDATIVE STRESS; CANCER RISK;

D O I：

10.3390/ijms20061305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer's disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin's key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.

引用

页数：26

共 159 条

[1] Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases [J].

Abenavoli, Ludovico ;

Izzo, Angelo A. ;

Milic, Natasa ;

Cicala, Carla ;

Santini, Antonello ;

Capasso, Raffaele .

PHYTOTHERAPY RESEARCH, 2018, 32 (11) :2202-2213

[2] Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation [J].

Al Shaal, Loaye ;

Shegokar, Ranjita ;

Mueller, Rainer H. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 420 (01) :133-140

[3] Health functionality of apigenin: A review [J].

Ali, Fahad ;

Rahul ;

Naz, Falaq ;

Jyoti, Smita ;

Siddique, Yasir Hasan .

INTERNATIONAL JOURNAL OF FOOD PROPERTIES, 2017, 20 (06) :1197-1238

[4]

Alibabaei Z., 2014, Biomedicine & Aging Pathology, V4, P355, DOI 10.1016/j.biomag.2014.07.003

[5]

Alqasoumi SI, 2013, PAK J PHARM SCI, V26, P999

[6] Influence of postharvest processing and storage on the content of phenolic acids and flavonoids in foods [J].

Amarowicz, Ryszard ;

Carle, Reinhold ;

Dongowski, Gerhard ;

Durazzo, Alessandra ;

Galensa, Rudolf ;

Kammerer, Dietmar ;

Maiani, Guiseppe ;

Piskula, Mariusz K. .

MOLECULAR NUTRITION & FOOD RESEARCH, 2009, 53 :S151-S183

[7]

Amsterdam JD, 2012, ALTERN THER HEALTH M, V18, P44

[8]

Andrade LM, 2018, MOJ Food Process Technol, V6, P45, DOI DOI 10.15406/MOJFPT.2018.06.00144

[9] Caecal absorption of vitexin-2-O-xyloside and its aglycone apigenin, in the rat [J].

Angelino, Donato ;

Berhow, Mark ;

Ninfali, Paolino ;

Jeffery, Elizabeth H. .

FOOD & FUNCTION, 2013, 4 (09) :1339-1345

[10]

[Anonymous], USDA DAT FLAV CONT S

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