The Cytokines of Asthma

被引：858

作者：

Lambrecht, Bart N. ^{[1
,2
,3
]}

Hammad, Hamida ^{[1
,2
]}

Fahy, John V. ^{[4
,5
]}

机构：

[1] VIB Ctr Inflammat Res, Lab Immunoregulat, Ghent, Belgium

[2] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium

[3] Erasmus MC, Dept Pulm Med, Rotterdam, Netherlands

[4] Univ Calif San Francisco, Dept Med, Div Pulm & Crit Care Med, San Francisco, CA USA

[5] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA USA

来源：

IMMUNITY | 2019年 / 50卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

INNATE LYMPHOID-CELLS; THYMIC STROMAL LYMPHOPOIETIN; HOUSE-DUST MITE; ALLERGIC AIRWAY INFLAMMATION; NATURAL HELPER-CELLS; NECROSIS-FACTOR-ALPHA; T-CELLS; DENDRITIC CELLS; DOUBLE-BLIND; TYPE-2; INFLAMMATION;

D O I：

10.1016/j.immuni.2019.03.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a chronic inflammatory airway disease associated with type 2 cytokincs interleukin-4 (IL-4), IL. and IL-13, whicn promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Here, we review the cytokine networks driving asthma, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic. We discuss established and emerging paradigms in the context of the growing appreciation of disease heterogeneity and argue that the development of new and improved therapeutics require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.

引用

页码：975 / 991

页数：17

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