30S ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli

被引：51
作者：
Mehta, R [1 ]
Champney, WS [1 ]
机构：
[1] E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol, Johnson City, TN 37614 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 05期
关键词：
D O I：
10.1128/AAC.46.5.1546-1549.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The aminoglycosides paromomycin and neomycin were examined in Escherichia coli cells for an inhibitory effect on 30S ribosomal subunit assembly. Both compounds inhibited the growth rate, viable cell number, and protein synthesis rate with similar 50% inhibitory concentrations. Each drug also showed a concentration-dependent inhibition of 30S subunit formation. The inhibitory effect on 30S particle formation was approximately equivalent to the inhibitory effect on translation for these antibiotics.
引用
收藏
页码：1546 / 1549
页数：4
相关论文
共 50 条
[41]   Mapping structural differences between 30S ribosomal subunit assembly intermediates [J].
Kristi L Holmes ;
Gloria M Culver .
Nature Structural & Molecular Biology, 2004, 11 :179-186
[42]   TOPOGRAPHY OF THE ESCHERICHIA-COLI RIBOSOMAL 30S SUBUNIT-INITIATION FACTOR-II COMPLEX [J].
WAKAO, H ;
ROMBY, P ;
EBEL, JP ;
GRUNBERGMANAGO, M ;
EHRESMANN, C ;
EHRESMANN, B .
BIOCHIMIE, 1991, 73 (7-8) :991-1000
[43]   LOCALIZATION OF THE DECODING REGION ON THE 30S ESCHERICHIA-COLI RIBOSOMAL-SUBUNIT BY AFFINITY IMMUNOELECTRON MICROSCOPY [J].
KERENZUR, M ;
BOUBLIK, M ;
OFENGAND, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (03) :1054-1058
[44]   Mapping structural differences between 30S ribosomal subunit assembly intermediates [J].
Holmes, KL ;
Culver, GM .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (02) :179-186
[45]   RNA CORE IN 30S RIBOSOMAL-SUBUNIT OF ESCHERICHIA-COLI AND ITS STRUCTURAL AND FUNCTIONAL SIGNIFICANCE [J].
GARRETT, RA ;
UNGEWICKELL, E ;
NEWBERRY, V ;
HUNTER, J ;
WAGNER, R .
CELL BIOLOGY INTERNATIONAL REPORTS, 1977, 1 (06) :487-502
[46]   High-throughput Mapping of Cotranscriptional Assembly of the 30S Ribosomal Subunit [J].
Yang, Feng ;
Kunde, Yuliya A. ;
Hennelly, Scott P. ;
Sanbonmatsu, Karissa Y. ;
Starkenburg, Shawn R. ;
Goodwin, Peter M. .
BIOPHYSICAL JOURNAL, 2018, 114 (03) :64A-64A
[47]   Neomycin and Paromomycin Inhibit 30S Ribosomal Subunit Assembly in Staphylococcus aureus [J].
Roopal Mehta ;
W. Scott Champney .
Current Microbiology, 2003, 47 :0237-0243
[48]   Phasing the 30S ribosomal subunit structure [J].
Brodersen, DE ;
Clemons, WM ;
Carter, AP ;
Wimberly, BT ;
Ramakrishnan, V .
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2003, 59 :2044-2050
[49]   PROBING DYNAMIC CHANGES IN RIBOSOMAL-RNA CONFORMATION IN THE 30S SUBUNIT OF THE ESCHERICHIA-COLI RIBOSOME [J].
WELLER, JW ;
HILL, WE .
BIOCHEMISTRY, 1992, 31 (10) :2748-2757
[50]   DETERMINATION OF STREPTOMYCIN SENSITIVITY BY A SUBUNIT OF 30S RIBOSOME OF ESCHERICHIA COLI [J].
STAEHELIN, T ;
MESELSON, M .
JOURNAL OF MOLECULAR BIOLOGY, 1966, 19 (01) :207-+
12345