RESEARCHING CONNECTIONS OF PRO12ALA POLYMORPHIC MARKERS OF THE PPARγ2 GENE WITH METABOLIC DISORDERS IN YAKUTIA'S INDIGENOUS POPULATION

被引：0
|
作者：
Ammosova, E. P. [1 ,2 ]
Klimova, T. M. [2 ,3 ]
Fedorov, A., I [4 ]
Baltakhinova, M. E. [5 ]
Zakharova, R. N. [6 ]
机构：
[1] NEFU Med Inst Sci Res Ctr, Yakutsk, Russia
[2] MK Ammosov North Eastern Fed Univ, Dept Pharmacol & Pharm, 27 Ulitsa Oiunskogo, Yakutsk 677000, Russia
[3] Yakutsk Sci Ctr Complex Med Problems, Dept Epidemiol Chron Noncommunicable Dis, Yakutsk, Russia
[4] MK Ammosov North Eastern Fed Univ, Med Inst, Res Lab Mol Med & Human Genet, 27 Ulitsa Oiunskogo, Yakutsk 677000, Russia
[5] Aurora Med Clin, 20-1 Ulitsa Poyarkova, Yakutsk, Russia
[6] MK Ammosov North Eastern Fed Univ, Med Inst, Res Ctr, 27 Ulitsa Oiunskogo, Yakutsk 677000, Russia
来源：
YAKUT MEDICAL JOURNAL | 2020年 / 03期
关键词：
PPAR gamma 2 gene; Pro12Ala polymorphic markers; obesity; metabolic syndrome; multiple metabolic risk factors; population; genetics; dyslipidemia; indigenous population; Yakutia; North; ACTIVATED RECEPTOR-GAMMA; DECREASED RISK; BODY-MASS; ASSOCIATION; RESISTANCE; OBESITY; SAKHA;
D O I：
10.25789/YMJ.2020.71.28
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This research aimed to study the association of the pro12Ala polymorphic markers of the PPAR gamma 2 gene with metabolic syndrome and its components in the indigenous inhabitants of Yakutia. We have examined 228 DNA samples of representatives of the Sakha (Yakut) nationality, permanently residing in the village of Berdigestyakh in the Gorny Ulus in Yakutia. Carriers of the Ala allele were quite often observed in the studied group (21.8%). Of these, the Pro/Ala genotype was established in 61 cases, and Ala/Ala in 2 cases. This distribution is generally not very typical for Asian populations. The results of the study did not reveal statistically significant associations of polymorphic markers of the PPAR gamma 2 gene (rs 1801282) with metabolic disorders.
引用
收藏
页码：108 / 111
页数：4
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