Cellular Heterogeneity and Molecular Evolution in Cancer

被引：381
作者：
Almendro, Vanessa [1 ,2 ,3 ]
Marusyk, Andriy [1 ,2 ]
Polyak, Kornelia [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA
[3] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, Dept Med Oncol, E-08036 Barcelona, Spain
来源：
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8 | 2013年 / 8卷
关键词：
intratumor heterogeneity; clonal selection; cancer stem cells; Darwinian evolution; biomarkers; IN-SITU HYBRIDIZATION; GENE-EXPRESSION PROFILES; ACUTE MYELOID-LEUKEMIA; PRIMARY BREAST-CANCER; SURROGATE END-POINTS; LUNG-CANCER; INTRATUMOR HETEROGENEITY; TUMOR HETEROGENEITY; CLONAL EVOLUTION; STEM-CELL;
D O I：
10.1146/annurev-pathol-020712-163923
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Intratumor heterogeneity represents a major obstacle to effective cancer treatment and personalized medicine. However, investigators are now elucidating intratumor heterogeneity at the single-cell level due to improvements in technologies. Better understanding of the composition of tumors, and monitoring changes in cell populations during disease progression and treatment, will improve cancer diagnosis and therapeutic design. Measurements of intratumor heterogeneity may also be used as biomarkers to predict the risk of progression and therapeutic resistance. We summarize important considerations related to intratumor heterogeneity during tumor evolution. We also discuss experimental approaches that are commonly used to infer intratumor heterogeneity and describe how these methodologies can be translated into clinical practice.
引用
收藏
页码：277 / 302
页数：26
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