Mbandakamines A and B, Unsymmetrically Coupled Dimeric Naphthylisoquinoline Alkaloids, from a Congolese Ancistrocladus Species

被引：51

作者：

Bringmann, Gerhard ^{[1
]}

Lombe, Blaise Kimbadi ^{[1
,2
]}

Steinert, Claudia ^{[1
]}

Ioset, Karine Ndjoko ^{[1
]}

Brun, Reto ^{[3
,4
]}

Turini, Florian ^{[5
]}

Heubl, Guenther ^{[5
]}

Mudogo, Virima ^{[2
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Kinshasa, Fac Sci, Kinshasa 11, DEM REP CONGO

[3] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

[4] Univ Basel, CH-4003 Basel, Switzerland

[5] Univ Munich, Dept Biol 1, Sect Systemat Bot, D-80638 Munich, Germany

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 11期

关键词：

ACETOGENIC ISOQUINOLINE ALKALOIDS; MICHELLAMINES; KORUPENSAMINE; AXES;

D O I：

10.1021/ol4005883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mbandakamines A (1) and B (2), isolated from the leaves of an as yet unidentified Congolese Ancistrocladus species, are the first dimeric naphthylisoquinoline alkaloids with an unsymmetrically coupled central biaryl axis. Their novel 6',1 ''-coupling type implies a hitherto unprecedented pen pen coupling in one of the naphthalene parts, leading to the as yet highest steric hindrance at the central axis and a total of seven elements of chirality. Mbandakamine A exhibits good antimalarial activity.

引用

页码：2590 / 2593

页数：4

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