Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events -: The Scottish Heart Health Study cohort

被引:14
|
作者
Tavendale, R [1 ]
Parratt, D
Pringle, SD
A'Brook, R
Tunstall-Pedoe, H
机构
[1] Univ Dundee, Ninewells Hosp & Med Sch, Cardiovasc Epidemiol Unit, Dundee DD1 9SY, Scotland
[2] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland
[3] Ninewells Hosp & Med Sch, Dept Cardiol, Dundee, Scotland
关键词
coronary artery disease; Chlamydia pneumoniae infection; epidemiology; immune complexes;
D O I
10.1053/euhj.2001.2778
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort. we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7.5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3%, vs 3%, respectively). The odds ratio for a coronary event was 1.00 (95% confidence interval 0.59-1.69) for the presence of IgG antibodies to C. pneumoniae 1.21 (0.76-1.92) for IgA and 0.75 (0.17-3.35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C pneumoniae antigen also showed no case-control differences (12% vs 12%. both sexes combined) with an odds ratio of 1.00 (0.57-1.76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease. (C) 2001 The European Society of Cardiology.
引用
收藏
页码:301 / 307
页数:7
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