Contemporary Trends in Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Low to Moderate Risk of Stroke After Guideline-Recommended Change in Use of the CHADS2 to the CHA2DS2-VASc Score for Thromboembolic Risk Assessment Analysis From the National Cardiovascular Data Registry's Outpatient Practice Innovation and Clinical Excellence Atrial Fibrillation Registry

Background-Use of the CHA(2)DS(2)-VASc score instead of the CHADS(2) score for thromboembolic risk stratification and initiation of oral anticoagulation (OAC) was recommended in the 2014 American Heart Association/American College of Cardiology/Heart Rhythm Society atrial fibrillation (AF) guidelines. We sought to define the proportion of patients with AF qualifying for and receiving OAC in contemporary practice by applying the CHA(2)DS(2)-VASc score to patients with a low CHADS(2) score. Methods and Results-Among patients with AF enrolled in the American College of Cardiology National Cardiovascular Data Registry's outpatient Practice Innovation and Clinical Excellence registry (2008-2014) CHADS(2) score of 0 or 1, we calculated the impact of adoption of the CHA(2)DS(2)-VASc score on the proportion of patients with an indication for OAC. We examined trends in prescription of OAC overall, direct OAC (dabigatran/rivaroxaban/apixaban), and multivariable associations between clinical characteristics and OAC use. Of 346 068 patients with AF aged 65 +/- 12 years, 61% were men and 65% were white. In total, 24% of those with CHADS(2)=0 and 81% of those with a CHADS(2)=1 were reclassified as having a definite indication for OAC (CHA(2)DS(2)-VASc score >= 2). OAC use increased from 37% to 48% during the study period, and direct OAC use increased from 5% to 30%. Increasing CHA(2)DS(2)-VASc score (odds ratio, 2.07; 95% confidence interval, 1.97-2.19 for score of 4 versus 0) and rhythm control strategy (odds ratio, 1.34; 95% confidence interval, 1.30-1.39) were associated with increased OAC use. Conclusions-Adoption of the CHA(2)DS(2)-VASc score reclassifies 64.5% of patients with AF with low CHADS(2) scores into a class I indication for OAC prescription. Overall OAC prescription increased between 2011 and 2014.