Combinatorial synthesis of unsymmetrical secondary amines. Application to arylethanolamines, arylpropanolamines and aryloxypropanolamines

被引：13

作者：

Rastogi, SK ^{[1
]}

Gupta, P ^{[1
]}

Srinivasan, T ^{[1
]}

Kundu, B ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

MOLECULAR DIVERSITY | 2000年 / 5卷 / 02期

关键词：

arylalkanolamines; arylpropanolamines; combinatoriallibraries; solid phase synthesis;

D O I：

10.1023/A:1013884926081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Combinatorial libraries of unsymmetrical secondary amines: arylethanolamine, arylpropanolamines and aryloxypropanolamines [1], in particular have been synthesized by four different routes using styrenes, aldehydes, hydroxyaromatic acids and bromoaliphatic acids. The structurally diverse libraries were generated in parallel format using solid phase methodology. The compounds corresponding to prototype I-IV were obtained in high yields and purities.

引用

页码：91 / 104

页数：14

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