Hemodynamics mediated epigenetic regulators in the pathogenesis of vascular diseases

被引：9
作者：
Karthika, C. L. [1 ]
Ahalya, S. [1 ]
Radhakrishnan, N. [2 ]
Kartha, C. C. [3 ]
Sumi, S. [1 ]
机构：
[1] Rajiv Gandhi Ctr Biotechnol, Cardiovasc Dis & Diabet Biol, Thiruvananthapuram 695014, Kerala, India
[2] St Thomas Inst Res Venous Dis, Changanassery, Kerala, India
[3] Kerala Inst Med Sci, Soc Continuing Med Educ & Res SOCOMER, Thiruvananthapuram, Kerala, India
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 01期
关键词：
Hemodynamics; Epigenetics; Mechanosensor; Endothelial cell; Atherosclerosis; Venous disease; SMOOTH-MUSCLE-CELLS; FLOW-DEPENDENT REGULATION; KRUPPEL-LIKE FACTORS; SHEAR-STRESS; DNA METHYLATION; FLUID SHEAR; GENE-EXPRESSION; DISTURBED FLOW; PULMONARY-HYPERTENSION; HISTONE DEACETYLASES;
D O I：
10.1007/s11010-020-03890-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endothelium of blood vessels is continuously exposed to various hemodynamic forces. Flow-mediated epigenetic plasticity regulates vascular endothelial function. Recent studies have highlighted the significant role of mechanosensing-related epigenetics in localized endothelial dysfunction and the regional susceptibility for lesions in vascular diseases. In this article, we review the epigenetic mechanisms such as DNA de/methylation, histone modifications, as well as non-coding RNAs in promoting endothelial dysfunction in major arterial and venous diseases, consequent to hemodynamic alterations. We also discuss the current challenges and future prospects for the use of mechanoepigenetic mediators as biomarkers of early stages of vascular diseases and dysregulated mechanosensing-related epigenetic regulators as therapeutic targets in various vascular diseases.
引用
收藏
页码：125 / 143
页数：19
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