Chronic Myelogenous Leukemia Presenting in Blast Phase with Nodal, Bilineal Myeloid Sarcoma and T-Lymphoblastic Lymphoma in a Child

被引：18

作者：

Chen, Xueyan ^{[1
]}

Rutledge, Joe C. ^{[1
,2
]}

Wu, David ^{[1
]}

Fang, Min ^{[3
,4
]}

Opheim, Kent E. ^{[1
,2
]}

Xu, Min ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[2] Seattle Childrens Hosp, Dept Labs, Seattle, WA USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2013年 / 16卷 / 02期

关键词：

acute lymphoblastic leukemia/lymphoma; acute myeloid leukemia; chronic myelogenous leukemia; myeloid sarcoma; CRISIS; MANIFESTATION;

D O I：

10.2350/12-07-1230-CR.1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A 14-year-old boy presented with chronic myelogenous leukemia (CML) in blast phase with segregated extramedullary (nodal) myeloid sarcoma and T-lymphoblastic lymphoma. Immunohistochemical stains performed on the lymphadenectomy sample demonstrated T lymphoblasts in the lymph nodes and myeloblasts in the adjacent soft tissue. Fluorescence in situ hybridization performed on paraffin sections confirmed that both T-lymphoblast and myeloblast populations were positive for the t(9;22) BCR/ABL1 translocation. Subsequent flow cytometry analysis of the bone marrow showed expanded populations of abnormal myeloblasts and T lymphoblasts diagnostic of blast phase CML. To the best of our knowledge, bilineal blast phase of CML with segregated extramedullary T lymphoblasts and myeloblasts has not been reported.

引用

页码：91 / 96

页数：6

共 15 条

[1]

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[2]

[Anonymous], LEUKEMIA LYMPHOMA

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