Redox-sensitive changes in conformation and cellular localization of LAT and downstream TCR signaling lead to hyporesponsiveness of synovial fluid T cells in rheumatoid arthritis

被引：0
|
作者：
Gringhuis, S. I. [1 ]
Remans, P. H. J. [1 ]
Papendrecht-van der Voort, E. A. M. [1 ]
Leow, A. [1 ]
Levarht, E. W. N. [1 ]
Breedveld, F. C. [1 ]
Verweij, C. L. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
来源：
ARTHRITIS RESEARCH & THERAPY | 2001年 / 3卷 / Suppl 2期
关键词：
Rheumatoid Arthritis; Rheumatoid Arthritis Patient; Synovial Fluid; Inflame Joint; Mediate Signaling Pathway;
D O I：
10.1186/ar207
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
P38
引用
收藏
页数：1
相关论文
共 12 条
  • [1] Redox-sensitive changes in conformation and cellular localization of LAT and downstream TCR signaling lead to hyporesponsiveness of synovial fluid T cells in rheumatoid arthritis
    SI Gringhuis
    PHJ Remans
    EAM Papendrecht-van der Voort
    A Leow
    EWN Levarht
    FC Breedveld
    CL Verweij
    Arthritis Research & Therapy, 3
  • [2] Hyporesonsiveness of synovial fluid T cells in rheumatoid arthritis due to redox-sensitive conformational changes of LAT.
    Gringhuis, SI
    Papendrecht-van der Voort, EAM
    Leow, A
    Breedveld, FC
    Verweij, CL
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S260 - S260
  • [3] Redox Balance Alterations and Hyporesponsiveness of Synovial T Cells in Rheumatoid Arthritis
    Breedveld, Ferdinand C.
    Gringhuis, S. I.
    Maurice, M. M.
    Verweij, C. L.
    ARTHRITIS RESEARCH & THERAPY, 1999, 1
  • [4] Redox Balance Alterations and Hyporesponsiveness of Synovial T Cells in Rheumatoid Arthritis
    Ferdinand C Breedveld
    SI Gringhuis
    MM Maurice
    CL Verweij
    Arthritis Research & Therapy, 1 (Suppl 1)
  • [5] Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis
    Maurice, MM
    Nakamura, H
    vanderVoort, EAM
    vanVliet, AI
    Staal, FJT
    Tak, PP
    Breedveld, FC
    Verweij, CL
    JOURNAL OF IMMUNOLOGY, 1997, 158 (03): : 1458 - 1465
  • [6] Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis
    Maurice, MM
    Lankester, AC
    Bezemer, AC
    Geertsma, MF
    Tak, PP
    Breedveld, FC
    vanLier, RAW
    Verweij, CL
    ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 1206 - 1206
  • [7] Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis
    Maurice, MM
    Lankester, AC
    Bezemer, AC
    Geertsma, MF
    Tak, PP
    Breedveld, FC
    vanLier, RAW
    Verweij, CL
    JOURNAL OF IMMUNOLOGY, 1997, 159 (06): : 2973 - 2978
  • [8] Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways
    Gringhuis, SI
    Papendrecht-van der Voort, EAM
    Leow, A
    Levarht, EWN
    Breedveld, FC
    Verweij, CL
    MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (02) : 400 - 411
  • [9] Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
    Gringhuis, SI
    Leow, A
    Papendrecht-van der Voort, EAM
    Remans, PHJ
    Breedveld, FC
    Verweij, CL
    JOURNAL OF IMMUNOLOGY, 2000, 164 (04): : 2170 - 2179
  • [10] Impaired TCR/CD3 signal transduction and intact costimulation in synovial T cells in rheumatoid arthritis: Features of an altered redox state.
    Maurice, MM
    vanderVoort, EA
    Levarht, N
    Breedveld, FC
    Verweij, CL
    ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 1722 - 1722
12