The interaction between the archaeal elongation factor 1α and its nucleotide exchange factor 1β

被引：8
|
作者：
Raimo, G [1 ]
Masullo, M [1 ]
Bocchini, V [1 ]
机构：
[1] Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, I-80131 Naples, Italy
来源：
FEBS LETTERS | 1999年 / 451卷 / 02期
关键词：
elongation factor 1 beta; exchange factor; Sulfolobus solfataricus; protein-protein interaction; Archaea;
D O I：
10.1016/S0014-5793(99)00560-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In Sulfolobus solfataricus the binding of the exchange factor 1 beta (SsEF-1 beta) to SsEF-1 alpha.GDP displaces the nucleotide and the SsEF-1 alpha.SsEF-1 beta complex is formed. The complex itself is stable, but it dissociates upon the addition of GDP or Gpp(NH)p but not ATP. Since the rate of the formation of the SsEF-1 alpha.SsEF-1 beta complex is significatively slower than the rate of the nucleotide exchange catalyzed by SsEF-1 beta it can be inferred that in vivo the GDP/GTP exchange reaction proceeds, ia an SsEF-1 alpha-SsEF-1 beta interaction without involving the formation of a stable binary complex as an intermediate. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：109 / 112
页数：4
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