Convenient synthesis of primary sulfonamides

被引：18

作者：

Greenfield, Alexander ^{[1
]}

Grosanu, Cristina ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 44期

关键词：

D O I：

10.1016/j.tetlet.2008.08.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol for a one-pot synthesis of mono-sulfonamides has been developed. It features utilization of excess of sulfonylating agent followed by base mediated recovery of the primary sulfonamide. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6300 / 6303

页数：4

共 10 条

[1]

HENDRICK.JB, 1973, TETRAHEDRON LETT, P4607

[2] A METHOD FOR THE REGIOSPECIFIC SYNTHESIS OF ENOL TRIFLATES BY ENOLATE TRAPPING [J].

MCMURRY, JE ;

SCOTT, WJ .

TETRAHEDRON LETTERS, 1983, 24 (10) :979-982

[3] Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors [J].

Parlow, JJ ;

Stevens, AM ;

Stegeman, RA ;

Stallings, WC ;

Kurumbail, RG ;

South, MS .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (20) :4297-4312

[4] Nimesulide - a multifactorial approach to inflammation and pain: scientific and clinical consensus [J].

Rainsford, K. D. .

CURRENT MEDICAL RESEARCH AND OPINION, 2006, 22 (06) :1161-1170

[5] Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells [J].

Su, Bin ;

Landini, Serena ;

Davis, Danyetta D. ;

Brueggemeier, Robert W. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (07) :1635-1644

[6] Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects [J].

Suh, YG ;

Lee, YS ;

Min, KH ;

Park, OH ;

Seung, HS ;

Kim, HD ;

Park, HG ;

Choi, JY ;

Lee, JW ;

Kang, SW ;

Oh, UT ;

Koo, JY ;

Joo, YH ;

Kim, SY ;

Kim, JK ;

Park, YH .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (24) :4389-4393

[7]

WINGARD L, 1991, HUMAN PHARM

[8] A REGIOSELECTIVE ENTRY TO VINYLLITHIUMS FROM UNSYMMETRICAL KETONES VIA ENOL TRIFLATES [J].

WULFF, WD ;

PETERSON, GA ;

BAUTA, WE ;

CHAN, KS ;

FARON, KL ;

GILBERTSON, SR ;

KAESLER, RW ;

YANG, DC ;

MURRAY, CK .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (02) :277-279

[9]

Yasuhara A, 1999, CHEM PHARM BULL, V47, P809

[10] Studies on anti-Helicobacter pylori agents.: Part 1:: Benzyloxyisoquinoline derivatives [J].

Yoshida, Y ;

Barrett, D ;

Azami, H ;

Morinaga, C ;

Matsumoto, S ;

Matsumoto, Y ;

Takasugi, H .

BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (11) :2647-2666

← 1 →