Stress-Strain Measurements in Vitrified Arteries Permeated With Synthetic Ice Modulators

被引：10

作者：

Eisenberg, David P. ^{[1
]}

Rabin, Yoed ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Mech Engn, Biothermal Technol Lab, Pittsburgh, PA 15232 USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2015年 / 137卷 / 08期

基金：

美国国家科学基金会;

关键词：

Young's modulus; mechanical behavior; cryogenics; cryopreservation; cryoprotective agent; DP6; synthetic ice modulator; blood vessels; THERMAL-EXPANSION; BLOOD-VESSELS; CRYOPRESERVATION; VITRIFICATION; DP6; DAMAGE; DMSO;

D O I：

10.1115/1.4030294

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This study measures the Young's modulus in vitrified blood vessels below the glass transition temperature in conditions relevant to cryogenic storage and focuses on the cryoprotective agents (CPAs) cocktail DP6 mixed with synthetic ice modulators (SIMs). Small steplike strain changes were observed during the loading without affecting the bulk behavior, suggesting microfracture occurrences resembling previous observation on microfracture formation under compression in crystallized blood vessels. Young's modulus was measured to be 0.92-3.01 GPa, with no clear indication of SIM dependency on the Young's modulus. Instead, the range of values is attributed to variations between specimens of the same species.

引用

页数：7

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