Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II)

被引：2

作者：

Na, Yu-Ran ^{[1
,2
]}

Woo, Dustin J. ^{[1
,3
]}

Choo, Hyunah ^{[3
,4
]}

Chung, Hak Suk ^{[1
,3
]}

Yang, Eun Gyeong ^{[1
,3
]}

机构：

[1] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 136791, South Korea

[2] Korea Univ, Res Inst Nat Sci, Dept Chem, Seoul 136701, South Korea

[3] Korea Univ Sci & Technol UST, Dept Biol Chem, Seoul 136791, South Korea

[4] Korea Inst Sci & Technol, Ctr Neuromed, Brain Sci Inst, Seoul 136791, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 53期

关键词：

ERYTHROPOIETIN GENE; HIF-ALPHA; FACTOR-I; BINDING; DESFERRIOXAMINE; COPPER;

D O I：

10.1039/c5cc02143j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein that Zn(II) selectively inhibits the hypoxia- inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.

引用

页码：10730 / 10733

页数：4

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