Hepatitis C Virus Infection Modulates Expression of Interferon Stimulatory Gene IFITM1 by Upregulating miR-130A

被引：88

作者：

Chowdhury, Joydip Bhanja ^{[2
]}

Shrivastava, Shubham ^{[2
]}

Steele, Robert ^{[2
]}

Di Bisceglie, Adrian M. ^{[1
,3
]}

Ray, Ranjit ^{[1
,3
]}

Ray, Ratna B. ^{[1
,2
,3
]}

机构：

[1] St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA

[2] St Louis Univ, Dept Pathol, St Louis, MO 63103 USA

[3] St Louis Univ, Ctr Liver, St Louis, MO 63103 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 18期

基金：

美国国家卫生研究院;

关键词：

WEST NILE VIRUS; POSTTRANSCRIPTIONAL REGULATION; HEPATOCELLULAR-CARCINOMA; DENGUE VIRUS; MICRORNAS; PROTEINS; IDENTIFICATION;

D O I：

10.1128/JVI.00882-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have examined the underlying mechanism of hepatitis C virus (HCV)-mediated IFITM1 regulation. IFITM1 is a potential target of miR-130a. Our results demonstrated that miR-130a expression was significantly higher in HCV-infected hepatocytes and liver biopsy specimens than in controls. Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication.

引用

页码：10221 / 10225

页数：5

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