New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide

被引：564
作者：
Feng, Lingyan [1 ]
Wu, Li [1 ]
Qu, Xiaogang [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Div Biol Inorgan Chem,Grad Sch, State Key Lab Rare Earth Resource Utilizat,Lab Ch, Changchun 130022, Jilin, Peoples R China
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 02期
关键词：
graphene; alzheimer's disease; telomerase; photothermal therapy; stem cells; NITROGEN-DOPED GRAPHENE; TURN-ON DETECTION; POSITRON-EMISSION-TOMOGRAPHY; RESONANCE ENERGY-TRANSFER; NEAR-INFRARED ABSORBENCY; FIELD-EFFECT TRANSISTORS; FUNCTIONALIZED GRAPHENE; PHOTOTHERMAL THERAPY; DRUG-DELIVERY; CARBON NANOTUBES;
D O I：
10.1002/adma.201203229
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Graphene, a one-atom-thick two-dimensional (2D) layer of sp2-bonded carbon, has received worldwide attention owing to its extraordinary physical and chemical properties. Recently, great efforts have been devoted to explore potential applications of graphene and its oxide in life science, especially in disease-related diagnostics, near-Infrared (NIR) phototherapy and imaging. Here we will introduce recent advances and new horizons in this area, and focus on the rising progress on NIR photothermal therapy for cancer and Alzheimer's disease (AD), human telomerase detection, stem cell proliferation and differentiation on graphene substrate, diagnosis of cancer cell and related biomarkers, drug/nucleotide/peptide delivery and cell imaging, which have not been comprehensively reviewed. We hope to provide an outlook to the applications of graphene and its oxide, especially on the new horizons in this field, and inspire broader interests across various disciplines.
引用
收藏
页码：168 / 186
页数：19
相关论文
共 206 条
[61]   EXPRESSION AND FUNCTION OF DROSOPHILA CYCLIN-A DURING EMBRYONIC-CELL CYCLE PROGRESSION [J].
LEHNER, CF ;
OFARRELL, PH .
CELL, 1989, 56 (06) :957-968
[62]   Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion [J].
Lei, Haozhi ;
Mi, Lijuan ;
Zhou, Xuejiao ;
Chen, Jiajia ;
Hu, Jun ;
Guo, Shouwu ;
Zhang, Yi .
NANOSCALE, 2011, 3 (09) :3888-3892
[63]   Processable aqueous dispersions of graphene nanosheets [J].
Li, Dan ;
Mueller, Marc B. ;
Gilje, Scott ;
Kaner, Richard B. ;
Wallace, Gordon G. .
NATURE NANOTECHNOLOGY, 2008, 3 (02) :101-105
[64]   A graphene-enhanced molecular beacon for homogeneous DNA detection [J].
Li, Fan ;
Huang, Yan ;
Yang, Qing ;
Zhong, Zentao ;
Li, Di ;
Wang, Lihua ;
Song, Shiping ;
Fan, Chunhai .
NANOSCALE, 2010, 2 (06) :1021-1026
[65]   Electrochemical immunosensors for cancer biomarker with signal amplification based on ferrocene functionalized iron oxide nanoparticles [J].
Li, He ;
Wei, Qin ;
He, Jing ;
Li, Ting ;
Zhao, Yanfang ;
Cai, Yanyan ;
Du, Bin ;
Qian, Zhiyong ;
Yang, Minghui .
BIOSENSORS & BIOELECTRONICS, 2011, 26 (08) :3590-3595
[66]   Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two-Photon Luminescence Imaging and Cell Therapy [J].
Li, Jing-Liang ;
Bao, Hong-Chun ;
Hou, Xue-Liang ;
Sun, Lu ;
Wang, Xun-Gai ;
Gu, Min .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (08) :1830-1834
[67]   A graphene oxide platform for energy transfer-based detection of protease activity [J].
Li, Juan ;
Lu, Chun-Hua ;
Yao, Qiu-Hong ;
Zhang, Xiao-Long ;
Liu, Jing-Jing ;
Yang, Huang-Hao ;
Chen, Guo-Nan .
BIOSENSORS & BIOELECTRONICS, 2011, 26 (09) :3894-3899
[68]   Fabrication of Graphene-Quantum Dots Composites for Sensitive Electrogenerated Chemiluminescence Immunosensing [J].
Li, Ling-Ling ;
Liu, Kun-Ping ;
Yang, Guo-Hai ;
Wang, Chun-Ming ;
Zhang, Jian-Rong ;
Zhu, Jun-Jie .
ADVANCED FUNCTIONAL MATERIALS, 2011, 21 (05) :869-878
[69]   Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease [J].
Li, Meng ;
Yang, Xinjian ;
Ren, Jinsong ;
Qu, Konggang ;
Qu, Xiaogang .
ADVANCED MATERIALS, 2012, 24 (13) :1722-1728
[70]   The promotion of neurite sprouting and outgrowth of mouse hippocampal cells in culture by graphene substrates [J].
Li, Ning ;
Zhang, Xuemin ;
Song, Qin ;
Su, Ruigong ;
Zhang, Qi ;
Kong, Tao ;
Liu, Liwei ;
Jin, Gang ;
Tang, Mingliang ;
Cheng, Guosheng .
BIOMATERIALS, 2011, 32 (35) :9374-9382
234567891011