Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks

被引:2
作者
Joyce, M. Gordon [1 ,2 ]
Wheatley, Adam K. [3 ]
Modjarrad, Kayvon [1 ]
机构
[1] Walter Reed Army Inst Res, Emerging Infect Dis Branch, Silver Spring, MD 20910 USA
[2] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA
[3] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
D O I
10.1016/j.cell.2020.06.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus spike glycoprotein and detail novel pathways to rapidly identify and characterize protective monoclonal antibodies.
引用
收藏
页码:7 / 9
页数:3
相关论文
共 10 条
[1]  
Cao Y., 2020, CELL, V182, P1
[2]  
Chi X., 2020, SCIENCE, P1
[3]   Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses [J].
Joyce, M. Gordon ;
Wheatley, Adam K. ;
Thomas, Paul V. ;
Chuang, Gwo-Yu ;
Soto, Cinque ;
Bailer, Robert T. ;
Druz, Aliaksandr ;
Georgiev, Ivelin S. ;
Gillespie, Rebecca A. ;
Kanekiyo, Masaru ;
Kong, Wing-Pui ;
Leung, Kwanyee ;
Narpala, Sandeep N. ;
Prabhakaran, Madhu S. ;
Yang, Eun Sung ;
Zhang, Baoshan ;
Zhang, Yi ;
Asokan, Mangaiarkarasi ;
Boyington, Jeffrey C. ;
Bylund, Tatsiana ;
Darko, Sam ;
Lees, Christopher R. ;
Ransier, Amy ;
Shen, Chen-Hsiang ;
Wang, Lingshu ;
Whittle, James R. ;
Wu, Xueling ;
Yassine, Hadi M. ;
Santos, Celia ;
Matsuoka, Yumiko ;
Tsybovsky, Yaroslav ;
Baxa, Ulrich ;
Mullikin, James C. ;
Subbarao, Kanta ;
Douek, Daniel C. ;
Graham, Barney S. ;
Koup, Richard A. ;
Ledgerwood, Julie E. ;
Roederer, Mario ;
Shapiro, Lawrence ;
Kwong, Peter D. ;
Mascola, John R. ;
McDermott, Adrian B. .
CELL, 2016, 166 (03) :609-623
[4]  
Juno J A., Infectious Diseases (except HIV/AIDS), P2020, DOI DOI 10.1101/2020.05.17.20104869
[5]   Stable long-term cultures of self-renewing B cells and their applications [J].
Kwakkenbos, Mark J. ;
van Helden, Pauline M. ;
Beaumont, Tim ;
Spits, Hergen .
IMMUNOLOGICAL REVIEWS, 2016, 270 (01) :65-77
[6]  
Salazar E, 2020, AM J PATHOL, V190, P1680, DOI [10.1016/j.ajpath.2020.05.014, 10.1016/j.ajpath.2020.10.008]
[7]   A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 [J].
Shi, Rui ;
Shan, Chao ;
Duan, Xiaomin ;
Chen, Zhihai ;
Liu, Peipei ;
Song, Jinwen ;
Song, Tao ;
Bi, Xiaoshan ;
Han, Chao ;
Wu, Lianao ;
Gao, Ge ;
Hu, Xue ;
Zhang, Yanan ;
Tong, Zhou ;
Huang, Weijin ;
Liu, William Jun ;
Wu, Guizhen ;
Zhang, Bo ;
Wang, Lan ;
Qi, Jianxun ;
Feng, Hui ;
Wang, Fu-Sheng ;
Wang, Qihui ;
Gao, George Fu ;
Yuan, Zhiming ;
Yan, Jinghua .
NATURE, 2020, 584 (7819) :120-+
[8]  
Walls AC, 2020, CELL, V181, P281, DOI [10.1016/j.cell.2020.02.058, 10.1016/j.cell.2020.11.032]
[9]   Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape [J].
Wang, Lingshu ;
Shi, Wei ;
Chappell, James D. ;
Joyce, M. Gordon ;
Zhang, Yi ;
Kanekiyo, Masaru ;
Becker, Michelle M. ;
van Doremalen, Neeltje ;
Fischer, Robert ;
Wang, Nianshuang ;
Corbett, Kizzmekia S. ;
Choe, Misook ;
Mason, Rosemarie D. ;
Van Galen, Joseph G. ;
Zhou, Tongqing ;
Saunders, Kevin O. ;
Tatti, Kathleen M. ;
Haynes, Lia M. ;
Kwong, Peter D. ;
Modjarrad, Kayvon ;
Kong, Wing-Pui ;
McLellan, Jason S. ;
Denison, Mark R. ;
Munster, Vincent J. ;
Mascola, John R. ;
Graham, Barney S. .
JOURNAL OF VIROLOGY, 2018, 92 (10)
[10]  
Wrapp D, 2020, SCIENCE, V367, P1260, DOI [10.1126/science.abb2507, 10.1101/2020.02.11.944462]