Synthesis of N-Alkyl-Substituted 4-Quinolones via Tandem Alkenyl and Aryl C-N Bond Formation

被引：38

作者：

Shao, Jun ^{[1
]}

Huang, Xiaomei ^{[1
]}

Hong, Xiaohu ^{[1
]}

Liu, Bingxin ^{[1
]}

Xu, Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 12期

基金：

中国国家自然科学基金;

关键词：

alkynes; amination; cyclization; nitrogen heterocycles; domino reactions; ONE-POT SYNTHESIS; ANTIMALARIAL ACTIVITY; CATALYZED AMIDATION; ANTITUMOR AGENTS; NS3; PROTEASE; CYCLIZATION; DERIVATIVES; QUINOLONE; 2-PHENYL-4-QUINOLONE; 2-ARYL-4-QUINOLONES;

D O I：

10.1055/s-0031-1290775

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields from easily accessible o-chloroaryl acetylenic ketones and functionalized alkyl amines. The approach complements and extends our previous work. Compared with other reported methods, the current method provides a very simple and convenient route.

引用

页码：1798 / 1808

页数：11

共 43 条

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