Kinetic and thermodynamic analysis of degradation of doripenem in the solid state

被引：13

作者：

Cielecka-Piontek, Judyta ^{[1
]}

Jelinska, Anna ^{[1
]}

Dolhan, Agnieszka ^{[1
]}

Zalewski, Przemyslaw ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Fac Pharm, Dept Pharmaceut Chem, PL-60780 Poznan, Poland

来源：

INTERNATIONAL JOURNAL OF CHEMICAL KINETICS | 2012年 / 44卷 / 11期

关键词：

STABILITY; MEROPENEM; ERTAPENEM; QUANTIFICATION; INFUSION;

D O I：

10.1002/kin.20722

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The kinetic and thermodynamic parameters of degradation of doripenem were studied using a high-performance liquid chromatography method. In dry air, the degradation of doripenem was a first-order reaction depending on the substrate concentration. At increased relative air humidity, doripenem was degraded according to the autocatalysis kinetic model. The dependence ln k = f1/T) was described by the equations ln k = 5.10 +/- 13.06 - (7576 +/- 4939)(1/T) in dry air and ln k = 46.70 +/- 22.44 - (19,959 +/- 8031)(1/T) at 76.4% relative humidity (RH). The thermodynamic parameters Ea,Delta H?a, and Delta S?a of the degradation of doripenem were calculated. The dependence ln k = f (RH%) was described by the equation ln k = (0.155 +/- 0.077) x 10-1 (RH%) - (3.45 +/- 21.8)x 10-10. (c) 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 722728, 2012

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页码：722 / 728

页数：7

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