Are recently reported biomarkers helpful for early and accurate diagnosis of acute kidney injury?

被引：31
作者：
Barrera-Chimal, Jonatan
Bobadilla, Norma A. [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City 14000, DF, Mexico
来源：
BIOMARKERS | 2012年 / 17卷 / 05期
关键词：
NGAL; IL-18; Kim-1; Hsp72; cystatin C; NAG; L-FABP; GELATINASE-ASSOCIATED LIPOCALIN; ACID-BINDING PROTEIN; ACUTE-RENAL-FAILURE; CONTRAST-INDUCED NEPHROPATHY; ISCHEMIA-REPERFUSION INJURY; EARLY PREDICTIVE BIOMARKER; EARLY URINARY BIOMARKER; BETA-D-GLUCOSAMINIDASE; CYSTATIN C; CARDIAC-SURGERY;
D O I：
10.3109/1354750X.2012.680070
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Over the past few years and with the use of innovative genomic and proteomic tools, several molecules that their urinary concentration is modified during acute kidney injury have been identified and proposed as biomarkers. Among the most studied biomarkers are neutrophil gelatinase-associated lipocalin-2, kidney injury molecule-1, interleukin-18, cystatin C, N-acetyl-beta-D-glucosaminidase, liver fatty-acid binding protein, and heat shock protein 72. Here, we reviewed and compared the sensitivity and specificity of each biomarker for the appropriate diagnosis of acute kidney injury, as well as its ability to stratify renal injury and to monitor a renoprotective pharmacologic strategy.
引用
收藏
页码：385 / 393
页数：9
相关论文
共 98 条
[1]   Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori [J].
Alpizar-Alpizar, Warner ;
Laerum, Ole Didrik ;
Illemann, Martin ;
Ramirez, Jose A. ;
Arias, Adriana ;
Malespin-Bendana, Wendy ;
Ramirez, Vanessa ;
Lund, Leif R. ;
Borregaard, Niels ;
Nielsen, Boye Schnack .
VIRCHOWS ARCHIV, 2009, 455 (03) :225-233
[2]   Conventional markers of kidney function [J].
Bagshaw, Sean M. ;
Gibney, R. T. Noel .
CRITICAL CARE MEDICINE, 2008, 36 (04) :S152-S158
[3]   Hsp72 is an early and sensitive biomarker to detect acute kidney injury [J].
Barrera-Chimal, Jonatan ;
Perez-Villalva, Rosalba ;
Cortes-Gonzalez, Cesar ;
Ojeda-Cervantes, Marcos ;
Gamba, Gerardo ;
Morales-Buenrostro, Luis E. ;
Bobadilla, Norma A. .
EMBO MOLECULAR MEDICINE, 2011, 3 (01) :5-20
[4]   A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephrotic syndrome [J].
Bazzi, C ;
Petrini, C ;
Rizza, V ;
Arrigo, G ;
D'Amico, G .
KIDNEY INTERNATIONAL, 2000, 58 (04) :1732-1741
[5]   Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study [J].
Bennett, Michael ;
Dent, Catherine L. ;
Ma, Qing ;
Dastrala, Sudha ;
Grenier, Frank ;
Workman, Ryan ;
Syed, Hina ;
Ali, Salman ;
Barasch, Jonathan ;
Devarajan, Prasad .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (03) :665-673
[6]   Urinary biomarkers for acute kidney injury: perspectives on translation [J].
Coca, Steven G. ;
Parikh, Chirag R. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 3 (02) :481-490
[7]   Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans [J].
Cowland, JB ;
Borregaard, N .
GENOMICS, 1997, 45 (01) :17-23
[8]   Plasma neutrophil gelatinase-associated lipocalin is an early biomarker for acute kidney injury in an adult ICU population [J].
Cruz, Dinna N. ;
de Cal, Massimo ;
Garzotto, Francesco ;
Perazella, Mark A. ;
Lentini, Paolo ;
Corradi, Valentina ;
Piccinni, Pasquale ;
Ronco, Claudio .
INTENSIVE CARE MEDICINE, 2010, 36 (03) :444-451
[9]  
Csermely P, 2007, ADV EXP MED BIOL, V594, P55
[10]   Neutrophil Gelatinase-associated Lipocalin at ICU Admission Predicts for Acute Kidney Injury in Adult Patients [J].
de Geus, Hilde R. H. ;
Bakker, Jan ;
Lesaffre, Emmanuel M. E. H. ;
le Noble, Jos L. M. L. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (07) :907-914
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