Cooperative Catalysis Approach to Intramolecular Hydroacylation

被引：64

作者：

Beletskiy, Evgeny V. ^{[1
]}

Sudheer, Ch. ^{[1
]}

Douglas, Christopher J. ^{[1
]}

机构：

[1] Univ Minnesota Twin Cities, Dept Chem, Minneapolis, MN 55455 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 14期

关键词：

DIRECT INTERMOLECULAR HYDROACYLATION; PARALLEL KINETIC RESOLUTION; ENANTIOSELECTIVE HYDROFORMYLATION; ASYMMETRIC CATALYSIS; 4+2 CARBOCYCLIZATION; ADDITION-REACTIONS; BOND ACTIVATION; CHIRAL LIGANDS; C-H; ALDEHYDES;

D O I：

10.1021/jo300779q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.

引用

页码：5884 / 5893

页数：10

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