Cooperative Catalysis Approach to Intramolecular Hydroacylation

被引：63
作者：
Beletskiy, Evgeny V. [1 ]
Sudheer, Ch. [1 ]
Douglas, Christopher J. [1 ]
机构：
[1] Univ Minnesota Twin Cities, Dept Chem, Minneapolis, MN 55455 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 14期
关键词：
DIRECT INTERMOLECULAR HYDROACYLATION; PARALLEL KINETIC RESOLUTION; ENANTIOSELECTIVE HYDROFORMYLATION; ASYMMETRIC CATALYSIS; 4+2 CARBOCYCLIZATION; ADDITION-REACTIONS; BOND ACTIVATION; CHIRAL LIGANDS; C-H; ALDEHYDES;
D O I：
10.1021/jo300779q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.
引用
收藏
页码：5884 / 5893
页数：10
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